Chris Honan

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Heparan sulfate proteoglycans (HSPGs) play a key role in shaping the tumor microenvironment by presenting growth factors, cytokines, and other soluble factors that are critical for host cell recruitment and activation, as well as promoting tumor progression, metastasis, and survival. M402 is a rationally engineered, non-cytotoxic heparan sulfate (HS)(More)
Using a vaccine approach, we immunized New Zealand White rabbits with a peptide containing a region of cholesteryl ester transfer protein (CETP) known to be required for neutral lipid transfer function. These rabbits had significantly reduced plasma CETP activity and an altered lipoprotein profile. In a cholesterol-fed rabbit model of atherosclerosis, the(More)
damage in central nervous system and peripheral nervous system inflammatory demyelinating diseases: common and divergent pathways of dysfunction and tissue damage. (2015). A new era in the treatment of multiple sclerosis. (2014). Antibodies to neurofascin exacerbate adoptive transfer experimental autoimmune neuritis. (2014). Therapeutic approaches to(More)
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