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Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo.(More)
The Earth System Modeling Framework (ESMF) project is developing a standard software platform for Earth system models. The standard, which defines a component architecture and a support infrastructure, is being developed under open-software practices. Target applications range from operational numerical weather prediction to climate-system change and(More)
Pregabalin is an analogue of the inhibitory neurotransmitter gamma-aminobutyric acid. In preclinical models, it has shown activity as an analgesic agent. A randomized, double-blind, placebo-controlled, parallel-group trial was undertaken to compare pregabalin to placebo and 400 mg of ibuprofen using a dental pain model. Study medication was administered(More)
A randomised, double blind comparative study was undertaken to assess the efficacy of low level laser therapy in the reduction of postoperative pain and swelling in patients undergoing the extraction of bilaterally impacted mandibular third molar teeth. Healing of the sockets was also compared after 1 week. A group of 64 patients had one randomly-selected(More)
The Open/ADF tool allows the evaluation of derivatives of functions defined by a Fortran program. The derivative evaluation is performed by a Fortran code resulting from the analysis and transformation of the original program that defines the function of interest. Open/ADF has been designed with a particular emphasis on modularity, flexibility, and the use(More)
(I) Ocean State Estimation [1, 2] I Given: – a set of (possibly different types of) observations – a numerical model & set of initial / boundary conditions I Question: (estimation / optimal control problem) Find optimal trajectory consistent with observations within prior error I Approach: Minimize least square function J (~u) measuring model vs. data(More)
Heading drift error remains a problem in a standalone navigation system that uses only low cost MEMS IMU due to yaw error unobservability. This paper therefore proposes a shoe mounted IMU approach, integrated with ZUPT and building heading information in Kalman filter environment to reduce heading drift for pedestrian navigation application. There were no(More)
The late steps in assembly of capsular polysaccharides (CPS) and their translocation to the bacterial cell surface are not well understood. The Wza protein was shown previously to be required for the formation of the prototype group 1 capsule structure on the surface of Escherichia coli serotype K30 (Drummelsmith, J., and Whitfield, C. (2000) EMBO J. 19,(More)
Class I and class II MHC glycoproteins are highly polymorphic molecules that bind antigenic peptides and present them on cell surfaces for recognition by T lymphocytes. Even though MHC polymorphism has long been known to affect both peptide binding and recognition by the TCR, the role of individual amino acids of MHC proteins in these interactions is poorly(More)