Chris Heaton

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The ability to chemically couple proteins to LH(N)-fragments of clostridial neurotoxins and create novel molecules with selectivity for cells other than the natural target cell of the native neurotoxin is well established. Such molecules are able to inhibit exocytosis in the target cell and have the potential to be therapeutically beneficial where secretion(More)
A whole genome association study was performed in a phase 3 clinical trial conducted to evaluate a novel antipsychotic, iloperidone, administered to treat patients with schizophrenia. Genotypes of 407 patients were analyzed for 334,563 single nucleotide polymorphisms (SNPs). SNPs associated with iloperidone efficacy were identified within the neuronal PAS(More)
Administration of certain drugs (for example, antiarrhythmics, antihistamines, antibiotics, antipsychotics) may occasionally affect myocardial repolarization and cause prolongation of the QT interval. We performed a whole genome association study of drug-induced QT prolongation after 14 days of treatment in a phase 3 clinical trial evaluating the efficacy,(More)
A history and lessons to be learnt • Planning system reform • Undergrounding of transmission • Smart metering and smart grids • European Supergrid • Energy Security • Electric vehicles. The Institution of Engineering and Technology (IET) is one of the world's leading professional societies of engineers and technicians, with over 150,000 members in 127(More)
Earlier versions have been presented at University of New South Wales and Australian National University and we thank seminar participants for helpful comments and suggestions. We especially thank Randy Ilg of the Bureau of Labour Statistics for his prompt and helpful responses to many queries about the data. Abstract We consider the contribution of(More)
In this paper we present a new approach to the specification of dynamic factor models. Our model has three advantages over existing work. Firstly, it is based on a minimal-dimension state-space representation giving some gain in computational efficiency over existing methods. Secondly, it easily accommodates hypothesis tests about the order of the(More)
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