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- W. Ian McDonald, Alastair D Compston, +13 authors Jerry S. Wolinsky
- Annals of neurology
- 2001
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and… (More)
- Chris H. Polman, Stephen C. Reingold, +15 authors Jerry S. Wolinsky
- Annals of neurology
- 2011
New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system… (More)
- Chris H. Polman, Stephen C. Reingold, +11 authors Jerry S. Wolinsky
- Annals of neurology
- 2005
New diagnostic criteria for multiple sclerosis integrating magnetic resonance image assessment with clinical and other paraclinical methods were introduced in 2001. The "McDonald Criteria" have been… (More)
- Chris H. Polman, P. W. O'Connor, +11 authors Alfred W. Sandrock
- The New England journal of medicine
- 2006
BACKGROUND
Natalizumab is the first alpha4 integrin antagonist in a new class of selective adhesion-molecule inhibitors. We report the results of a two-year phase 3 trial of natalizumab in patients… (More)
- Ludwig Kappos, Ernst-Wilhelm Radue, +8 authors Pascale Burtin
- The New England journal of medicine
- 2010
BACKGROUND
Oral fingolimod, a sphingosine-1-phosphate-receptor modulator that prevents the egress of lymphocytes from lymph nodes, significantly improved relapse rates and end points measured on… (More)
- Frederik Barkhof, Massimo Filippi, +7 authors J. B. F. van der Valk
- Brain : a journal of neurology
- 1997
We compared MRI criteria used to predict conversion of suspected multiple sclerosis to clinically definite multiple sclerosis. Seventy-four patients with clinically isolated neurological symptoms… (More)
- Ludwig Kappos, Jack P. Antel, +7 authors Ernst Wilhelm Radue
- The New England journal of medicine
- 2006
BACKGROUND
Fingolimod (FTY720) is a new oral immunomodulating agent under evaluation for the treatment of relapsing multiple sclerosis.
METHODS
We randomly assigned 281 patients to receive oral… (More)
- Sergio E Baranzini, Nicholas W. Galwey, +12 authors Michael R. Barnes
- Human molecular genetics
- 2009
Genome-wide association studies (GWAS) testing several hundred thousand SNPs have been performed in multiple sclerosis (MS) and other complex diseases. Typically, the number of markers in which the… (More)
PURPOSE
To prospectively compare the depiction of intracortical lesions by using multislab three-dimensional (3D) double inversion-recovery (DIR), multislab 3D fluid-attenuated inversion-recovery… (More)
- Robert C. Axtell, Brigit A de Jong, +16 authors Chander Raman
- Nature Medicine
- 2010
Interferon-β (IFN-β) is the major treatment for multiple sclerosis. However, this treatment is not always effective. Here we have found congruence in outcome between responses to IFN-β in… (More)