Chris H. Franklin

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In fungi and mammals, the majority of meiotic recombination occurs in narrow (1–2 kb) hot spots1–3. Human and mouse hot spots are targeted to DNA sequence motifs by the zinc finger domain protein PRDM9 (refs. 4–11). PRDM9-dependent crossovers occur mainly in intergenic regions and introns, with the lowest amount of recombination occurring in exons9,12.(More)
During meiosis homologous chromosomes undergo crossover recombination. Sequence differences between homologs can locally inhibit crossovers. Despite this, nucleotide diversity and population-scaled recombination are positively correlated in eukaryote genomes. To investigate interactions between heterozygosity and recombination we crossed Arabidopsis lines(More)
Sexual reproduction in flowering plants is controlled by recognition mechanisms involving the male gametophyte (the pollen) and the female sporophyte (the pistil). Self-incompatibility (SI) involves the recognition and rejection of self- or incompatible pollen by the pistil. In Papaver rhoeas, SI uses a Ca(2+)-based signalling cascade triggered by the(More)
Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC), and albendazole are used in control programs for these diseases, but are mainly effective against the microfilarial stage and have minimal or no effect on(More)
Event-B [19] is a language for the formal specification and verification of reactive systems. The language and its RODIN toolkit represent a leading model-based technology for formal software construction. However, scalability is a major current concern, especially the dimension of reusability. We outline a proposed infrastructure for scalable development(More)
Whole genome duplication is a prominent feature of many highly evolved organisms, especially plants. When duplications occur within species, they yield genomes comprising multiple identical or very similar copies of each chromosome (“autopolyploids”). Such genomes face special challenges during meiosis, the specialized cellular program that underlies gamete(More)
Lothar Altschmied Susan J. Armstrong Janneke Balk Ian Bancroft Philippa Barell Frederic Berger Anuj Bhatt Ross Bicknell Raoul Bino Spencer Brown Giampiero Cai John G. Carman David D. Cass Veronique Chable Alice Cheung Adrienne E. Clarke Christophe Clément Nigel Crawford Mauro Cresti Rupali Datta Jan Derksen Hugh G. Dickinson Verónica S. Di Stilio Peter(More)