Chris Gouveia

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Lateral striate arteries were dissected from the fixed brains of 6 patients of increasing age. Small branches of arteries were observed--unprocessed and unstained--by Nomarski optics. Among the findings there was fibrous intimal proliferation, replacement of medial muscle by collagen, tortuosity, twisting or coiling. The severity of changes seemed to(More)
Heat shock protein 90 (HSP90) is a chaperone protein that stabilizes proteins involved in oncogenic and therapeutic resistance pathways of epithelial cancers, including head and neck squamous cell carcinomas (HNSCCs). Here, we characterized the molecular, cellular, and preclinical activity of HSP90 inhibitor SNX5422/2112 in HNSCC overexpressing HSP90.(More)
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