A modified version of the micturition model proposed by Hübener et al in 1994  is presented. Relations between variables in the model are derived and explained then simulations are compared to published urodynamical data. Finally, the model is compared to other published models, and its implications and limitations are discussed.
Salesforce.com has recently completed an agile transformation of a two hundred person team within a three month window. This is one of the largest and fastest " big-bang " agile rollouts. This experience report discusses why we chose to move to an agile process, how we accomplished the transformation and what we learned from applying agile at scale.
The urothelium is a newly recognized sensory structure that detects bladder fullness. Pivotal to this sensory role is the release of ATP from the urothelium. However, the routes for urothelial ATP release, its modulation by receptor-mediated pathways, and the autocrine/paracrine role of ATP are poorly understood, especially in native tissue. We examined the… (More)
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive deposition of extracellular matrix, worsening dyspnea, and eventual mortality. Pathogenesis of IPF is poorly understood and the role inflammation and activated leukocytes play in the disease process is controversial. Previous studies demonstrated that activated leukocyte subsets… (More)
HP offers many innovative products to meet diverse customer needs. The breadth of its product offerings has helped the company achieve unparalleled market reach; however, it has come with significant costs and challenges. By offering multiple similar products, a manufacturer increases its overall demand volatility, reduces forecast accuracy, and can… (More)