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OBJECTIVES To determine whether the use of medications with possible and definite anticholinergic activity increases the risk of cognitive impairment and mortality in older people and whether risk is cumulative. DESIGN A 2-year longitudinal study of participants enrolled in the Medical Research Council Cognitive Function and Ageing Study between 1991 and(More)
BACKGROUND Agitation in Alzheimer's disease (AD) is common and associated with poor patient life-quality and carer distress. The best evidence-based pharmacological treatments are antipsychotics which have limited benefits with increased morbidity and mortality. There are no memantine trials in clinically significant agitation but post-hoc analyses in other(More)
1 Generalized quantifiers in natural language semantics of The Handbook of Computational Linguistics and Natural Language Processing (Wiley-Blackwell. The online version of The Handbook of Artificial Intelligence by Avron Barr and Edward A. parsing, test generation, and natural language processing systems. Courses 1, 2 and 3 are the creation of Nitin(More)
V Preface CICLing 2006 (www.CICLing.org) was the 7th Annual Conference on Intelligent Text Processing and Computational Linguistics. The CICLing conferences are intended to provide a wide-scope forum for discussion of the internal art and craft of natural language processing research and the best practices in its applications. This volume contains the(More)
CONTEXT The cognitive side effects of medications with anticholinergic activity have been documented among older adults in a variety of clinical settings. However, there has been no systematic confirmation that acute or chronic prescribing of such medications lead to transient or permanent adverse cognitive outcomes. OBJECTIVE Evaluate the existing(More)
OBJECTIVE to examine the effect of medications with anticholinergic effects on cognitive impairment and deterioration in Alzheimer's dementia (AD). METHODS cognitive function was measured at baseline and at 6- and 18-month follow-up using the Mini-Mental State Exam (MMSE), the Severe Impairment Battery (SIB) and the Alzheimer's Disease Assessment Battery,(More)
BACKGROUND Previous Cochrane reviews have considered the use of cholinesterase inhibitors in both Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB). The clinical features of DLB and PDD have much in common and are distinguished primarily on the basis of whether or not parkinsonism precedes dementia by more than a year. Patients(More)
OBJECTIVES to determine the effect of drugs with anti-cholinergic properties on relevant health outcomes. DESIGN electronic published and unpublished literature/trial registries were systematically reviewed. Studies evaluating medications with anti-cholinergic activity on cognitive function, delirium, physical function or mortality were eligible. (More)
This paper shows how analysis of programs in terms of pre-and post-conditions can be improved using a gen-eralisation of conditioned program slicing called pre/post conditioned slicing. Such conditions play an important role in program comprehension, reuse, verification and re-engineering. Fully automated analysis is impossible because of the inherent(More)