Chris F Hayward

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In November 2013, a series of earthquakes began along a mapped ancient fault system near Azle, Texas. Here we assess whether it is plausible that human activity caused these earthquakes. Analysis of both lake and groundwater variations near Azle shows that no significant stress changes were associated with the shallow water table before or during the(More)
Additional structure-activity relationship studies on potent cyclic peptide inhibitors of very late antigen-4 (VLA-4) are reported. The new N- to C-terminal cyclic hexa-, hepta- and octapeptide inhibitors like cyclo(MeIle/MePhe-Leu-Asp-Val-X) (X = 2-4 amino acids containing hydrophobic and/or basic side chains) were synthesized using solid phase peptide(More)
Potent monomeric and dimeric cyclic peptide very late antigen-4 (VLA-4) inhibitors have been designed based on a tetrapeptide (Ile-Leu-Asp-Val) sequence present in a 25-amino acid peptide (CS-1) reported in the literature. The peptides, synthesized by the SPPS techniques, were evaluated in the in vitro cell adhesion assays and in the in vivo inflammation(More)
Alan Christopher Hayward, born 1932. Assoc. Prof. of Microbiology, U. of Queensland. B.Sc. (1953), Ph.D. in Bacteriology (1956), both at U. of Birmingham; 1956-58, Process Microbiologist, Port-of-Spain, Trinidad, West Indies; 1959-65, Bacteriologist at the former Commonwealth Mycological Inst., Kew, UK; 1965-68, Lecturer in Microbiology; 1968-78, Senior(More)
Stephen J. Arrowsmith,1 Rod Whitaker,1 Steven R. Taylor,2 Relu Burlacu,3 Brian Stump,4 Michael Hedlin,5 George Randall,1 Chris Hayward4 and Doug ReVelle1 1Los Alamos National Laboratory, PO Box 1663, Los Alamos, NM 87545, USA. E-mail: 2Rocky Mountain Geophysics, 167 Piedra Loop, Los Alamos, NM 87544, USA 3University of Utah Seismograph(More)
The GRP receptor mediated growth response in Swiss 3T3 cells has been used to identify BN/GRP antagonists. Analysis of bombesin antagonism by substance P analogues and by truncated GRP analogues revealed that deletion of the C-terminal methionine residue was important for antagonism. Des-Met analogues showing potent antagonist activity in the in vitro 3T3(More)
Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are(More)
This empirical study is designed to quantify mining explosions as sources of seismic and infrasound signals. The study focuses on the Western US, where a variety of different types of mining operations exist, ranging from surface coal cast blasting to hard rock fragmentation blasting in porphyry copper mines. The study is extended to the taconite mines of(More)
In Texas, earthquakes have occurred in close association with activities accompanying petroleum production since 1925. Here we develop a five-question test to categorize individual events as “tectonic,” “possibly induced,” “probably induced,” or “almost certainly induced.” In Texas, the probably induced and almost certainly induced earthquakes are broadly(More)