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Glycosylceramides in mammalian species are thought to be present in the form of β-anomers. This conclusion was reinforced by the identification of only one glucosylceramide and one galactosylceramide synthase, both β-transferases, in mammalian genomes. Thus, the possibility that small amounts of α-anomers could be produced by an alternative enzymatic(More)
OBJECTIVE Titin gene (TTN) mutations have been described in eight families with hereditary myopathy with early respiratory failure (HMERF). Some of the original patients had features resembling myofibrillar myopathy (MFM), arguing that TTN mutations could be a much more common cause of inherited muscle disease, especially in presence of early respiratory(More)
Particles to the rescue! The construction of cationic amino acid motifs on the surface of bacteriophage Qbeta by genetic engineering or chemical conjugation gives particles that are potent inhibitors of the anticoagulant action of heparin, which is a common anticlotting agent subject to clinical overdose.Polyvalent interactions allow biological structures(More)
NASA has recently instituted requirements for establishing Agency-level safety thresholds and goals that define long-term targeted and maximum tolerable levels of risk to the crew as guidance to developers in evaluating " how safe is safe enough " for a given type of mission. This paper discusses some key concepts regarding the role of the Agency's safety(More)
Probabilistic safety requirements currently formulated or proposed for space systems, nuclear reactor systems, nuclear weapon systems, and other types of systems that have a low probability potential for high consequence accidents depend on showing that the probability of such accidents is below a specified safety threshold or goal. Verification of(More)
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