Chris Dainty

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Cellular in vivo visualization of the three dimensional architecture of individual human foveal cone photoreceptors is demonstrated by combining ultrahigh resolution optical coherence tomography and a novel adaptive optics modality. Isotropic resolution in the order of 2-3µm, estimated from comparison with histology, is accomplished by employing an(More)
Ultrahigh-resolution adaptive optics–optical coherence tomography (UHR-AO-OCT) instrumentation allowing monochromatic and chromatic aberration correction was used for volumetric in vivo retinal imaging of various retinal structures including the macula and optic nerve head (ONH). Novel visualization methods that simplify AO-OCT data viewing are presented,(More)
Customized optical filtering and light-dependent neural filtering were implemented in an ideal-observer model for an L-alternative forced-choice visual task. The model was applied to a contrast threshold visual task with adaptive optics correction of ocular higher-order (HO) aberrations under different light regimes, for which experimental data have(More)
An adaptive optics vision simulator was used to measure the role of ocular aberrations in the photopic foveal spatial summation curve for three young subjects. After the correction of the ocular aberrations over a 6 mm pupil, the increment luminance threshold was lowered for small stimuli and the estimated area of complete summation (Ricco's area) was(More)
Custom high-resolution high-speed anterior segment spectral domain Optical Coherence Tomography (OCT) provided with automatic quantification and distortion correction algorithms was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo in four subjects, for accommodative demands between 0 to 6 D in 1 D steps. Anterior and(More)
We present a practical method for reconstructing the optical system of the human eye from off-axis wavefront measurements. A retinal beacon formed at different locations on the retina allows probing the optical structure of the eye by the outgoing beams that exit the eye through the dilated pupil. A Shack-Hartmann aberrometer measures the amount of wave(More)
Microfluctuations of accommodation have been the subject of many studies. New technological developments now permit us to study the dynamics of the microfluctuations with unprecedented resolution and accuracy. We aim to characterise their temporal statistics for different levels of accommodative effort, using a custom-built aberrometer. We conducted 46 s(More)
The time-evolution of ocular aberrations has been the subject of many studies, but so far there has been little discussion involving the modelling of the underlying temporal statistics. This paper presents a non-stationary modelling approach based on a coloured-noise generator, which can be applied to ocular aberration dynamics. The model parameters are(More)
Adaptive optics, when integrated into retinal imaging systems, compensates for rapidly changing ocular aberrations in real time and results in improved high resolution images that reveal the photoreceptor mosaic. Imaging the retina at high resolution has numerous potential medical applications, and yet for the development of commercial products that can be(More)
We show, both theoretically and experimentally, that high-numerical-aperture (NA) optical microscopy is accompanied by strong spin-orbit interaction of light, which translates fine information about the specimen to the polarization degrees of freedom of light. An 80 nm gold nanoparticle scattering the light in the focus of a high-NA objective generates(More)