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Congenital heart defects comprise the most common form of major birth defects, affecting 0.7% of all newborn infants. Jacobsen syndrome (11q-) is a rare chromosomal disorder caused by deletions in distal 11q. We have previously determined that a wide spectrum of the most common congenital heart defects occur in 11q-, including an unprecedented high(More)
Integration of active optical components typically serves five goals: enhanced performance, smaller size, lower power dissipation, higher reliability, and lower cost. We can differentiate between horizontal and vertical integration schemes. Horizontal integration combines many elements of the same functionality, like laser arrays. Vertical integration(More)
Acute respiratory distress syndrome (ARDS) is a poorly understood condition with greater than 30% mortality. Massive recruitment of neutrophils to the lung occurs in the initial stages of the ARDS. Significant variability in the severity and duration of ARDS-associated pulmonary inflammation could be linked to heterogeneity in the inflammatory capacity of(More)
—In this paper, the available analog link performance of integrated transmitters containing a sampled-grating distributed Bragg reflector laser, a semiconductor optical amplifier, and a modulator is evaluated. It is found that to provide a link gain and a low-noise figure, an RF preamplifier is required, and for this reason, spurious-free dynamic range(More)
Introduction Neutrophils have been involved in sepsis-induced organ damage. Neutrophils could be directly activated by TLR binding ligands including LPS. IRAK-1 is one of many intracellular proteins that are activated upon stimulation of TL receptors. This triggers a series of events that results in the migration of NF-κB into the nucleus and the activation(More)
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