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BACKGROUND Patients with end-stage renal disease (ESRD) have a high prevalence of sleep disorders, which are not improved by conventional hemodialysis (CHD). Although sleep disorders are commonly associated with complaints of excessive daytime sleepiness, the severity and pathogenesis of daytime sleepiness has not been evaluated objectively in patients with(More)
Professional societies throughout the world, ncluding the Canadian Society of Nephrology CSN), agree there is a need for developing linical practice guidelines for patients with hronic kidney disease (CKD). However, as illusrated by the case of the plethora of anemia uidelines for CKD that have been completed and updated) by many national professional(More)
Staff Working Papers are not for quotation without the permission of the authors. The views expressed in this paper are those of the staff involved and do not necessarily reflect those of the Productivity Commission. Information on the Productivity Commission, its publications and its current work program can be found on the World Wide Web at(More)
Implantable ventricular assist devices (VADs) have proven efficient in advanced heart failure patients as a bridge-to-transplant or destination therapy. However, VAD usage often leads to infection, bleeding, and thrombosis, side effects attributable to the damage to blood cells and plasma proteins. Measuring hemolysis alone does not provide sufficient(More)
Faecal urgency and incontinence with rectal hypersensitivity is a chronic, unexplained condition that is difficult to treat. The aim of this study was to determine if there was an altered level of the voltage gated tetrodotoxin-sensitive (TTX-s) sodium channel Na(v)1.7 in rectal sensory fibres, since this channel has been implicated in clinical nociceptive(More)
This article describes research related to the design of a payment model for specialty oncology services for possible testing by the Center for Medicare and Medicaid Innovation at the Centers for Medicare & Medicaid Services (CMS). Cancer is a common and costly condition. Episode-based payment, which aims to create incentives for high-quality, low-cost(More)
Defect detection and classification is crucial in ensuring product quality and reliability. Classification provides information on problems related to the detected defects which can then be used to perform yield prediction, fault diagnosis, correcting manufacturing issues and process control. Accurate classification requires good selection of features to(More)