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Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.

• Jared A. Gollob, Scott Wilhelm, Chris Carter, Susan L. Kelley
• Seminars in oncology
• 2006

Improvements in our understanding of the molecular basis of cancer have led to the clinical development of protein kinase inhibitors, which target pivotal molecules involved in intracellular… (More)

Hydroxyurea treatment of sickle cell anemia in hospital-based practices.

• Robert P. Ferguson, Anuradha Arun, Chris Carter, Stanley D. Walker, Oswaldo de Castro
• American journal of hematology
• 2002

In a published randomized clinical trial, hydroxyurea (HU) improved clinical outcomes in patients with sickle cell anemia (SCA). The mean treatment duration of that trial was 21 months. Here we… (More)

Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity.

• Maureen Andrew, Chris Carter, Hugh O'brodovich, George J. F. Heigenhauser
• Journal of applied physiology
• 1986

Components of the factor VIII complex increase and activation of the fibrinolytic system occur during exercise. The relation between the duration and intensity of exercise and the relative changes in… (More)

Using computed tomography to assist with diagnosis of avascular necrosis complicating chronic scaphoid nonunion.

• Michael L Smith, Gregory Ian Bain, Nick Chabrel, Philip Turner, Chris Carter, Justin Field
• The Journal of hand surgery
• 2009

PURPOSE The primary aim of our study was to investigate use of long axis computed tomography (CT) in predicting avascular necrosis of the proximal pole of the scaphoid and subsequent fracture… (More)

Implementing the severe sepsis care bundles outside the ICU by outreach.

• Chris Carter
• Nursing in critical care
• 2007

Sepsis is not a new challenge facing the health care team, it remains a complex disease, which is difficult to identify and treat. Mortality from sepsis remains high and continues to be a common… (More)

Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses.

• Richard W. Childs, Emmanuel Clave, +8 authors A. J. Barrett
• Blood
• 1999

Nonmyeloablative allogeneic stem cell transplantation has recently been explored as a safer alternative to conventional high-dose transplant regimens. Although a high incidence of mixed chimerism… (More)

Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in…

• Kenneth H. Cowan, Jeffrey A. Moscow, +22 authors A. W. Nienhuis
• Clinical cancer research : an official journal of…
• 1999

The MDR1 multidrug resistance gene confers resistance to natural-product anticancer drugs including paclitaxel. We conducted a clinical gene therapy study to determine whether retroviral-mediated… (More)

Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy.

• Jeffrey A. Moscow, Huayi Huang, +16 authors Kenneth H. Cowan
• Blood
• 1999

To determine whether the multidrug resistance gene MDR1 could act as a selectable marker in human subjects, we studied engraftment of peripheral blood progenitor cells (PBPCs) transduced with either… (More)

Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia.

• Ben Kennedy, Andy C Rawstron, +4 authors Peter Hillmen
• Blood
• 2002

Campath-1H (alemtuzumab) is the most effective monoclonal antibody in single-agent use in B-cell chronic lymphocytic leukemia (CLL) with reported response rates of 33% to 70%. Combination therapy is… (More)

Autoimmune haemolytic anaemia complicating ulcerative colitis.

• Dave Clements, Chris Carter, Robert N. Allan
• British journal of hospital medicine
• 1988

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