Chris Blackmore

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This final part of the book comprises just one chapter, written by Chris Blackmore, the editor of this book. This chapter is a synthesis of the main points made in all the chapters of the book by all the authors. First the context of ‘managing systemic change’ and the relevance of social learning systems and communities of practice for that purpose are(More)
BACKGROUND & AIMS The RegIalpha gene (Reg) encodes a secretory protein proposed to regulate islet beta-cell and gastric mucous cell growth. Reg is expressed in rat gastric enterochromaffin-like (ECL) cells. The aim of this study was to examine Reg expression in human corpus and to determine the identity of Reg in ECL cell carcinoid tumors in(More)
BACKGROUND & AIMS Amidated gastrins are acid secretagogues and growth factors. Their precursor, progastrin, is a growth factor but not a secretagogue. Cleavage of progastrin at Arg94/95 determines the expression of these two alternative patterns of biological activity. We examined the hypothesis that cleavage at Arg94/95 is regulated by phosphorylation of(More)
We offer a reflection on our own praxis as designers and developers of a learning system for mature-age students through the Open University (OU) UK’s internationally recognised supported-open learning approach. The learning system (or course or module), which required an investment in the range of £0.25–0.5 million to develop, thus reflects our own history(More)
Informed by first and second-order cybernetic understandings the case is made for the design of learning systems as a socially relevant form of praxis for situations of complexity, uncertainty and conflict. Two case studies of designing are considered. In the first, students of two versions of the Open University course ‘Environmental decision making: a(More)
1. The acidic interior of neuroendocrine secretory vesicles provides both an energy gradient for amine-proton exchangers (VMATs) to concentrate small transmitter molecules, for example catecholamines, and an optimal pH for the prohormone convertases which cleave hormone precursors. There is evidence that VMAT activity modulates prohormone cleavage, but in(More)
In 2015, water governance in England finds itself part way through perhaps the most significant changes since the privatisation of the water industry in 1989. Each of the changes is a response to the specific challenges that fall within the realm of improving water governance. However, they also raise many questions: How will the changes play out in(More)
This paper considers how learning for transformation of water governance in the context of climate change adaptation can be designed for and supported, drawing examples from the international climate change adaptation and water governance project (CADWAGO). The project explicitly set out to design for governance learning in the sense of developing elements(More)
Trust is often seen as an important element in settings of knowledge sharing and the co-creation of knowledge for dealing with transformations in water governance. However, seemingly similar conversations during a co-creation workshop in Uppsala resulted in both trust and distrust, and thereby influenced consequent possibilities for the co-creation of(More)