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An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening

• Anh Tuan Nguyen, Alexander Emelyanov, Chor Hui Vivien Koh, Jan M. Spitsbergen, Serguei Parinov, Zhiyuan Gong
• Disease models & mechanisms
• 2012

Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was… (More)

Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease.

• Chor Hui Vivien Koh, Nam Sang Cheung
• Cellular signalling
• 2006

Neuronal cell death can occur by means of either necrosis or apoptosis. Both necrosis and apoptosis are generally believed to be distinct mechanisms of cell death with different characteristic… (More)

Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons.

• Nam Sang Cheung, Chor Hui Vivien Koh, +5 authors Matthew Whiteman
• Biochemical and biophysical research…
• 2004

Niemann-Pick disease type C (NPC) is a juvenile neurodegenerative disorder characterized by premature neuronal loss and altered cholesterol metabolism. Previous reports applying an 8-h exposure of… (More)

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

• Anh Tuan Nguyen, Alexander Emelyanov, +5 authors Zhiyuan Gong
• Disease models & mechanisms
• 2011

Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and… (More)

Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons.

• Chor Hui Vivien Koh, Matthew Whiteman, +9 authors Nam Sang Cheung
• Journal of neurochemistry
• 2006

Findings that antioxidant treatment may be beneficial in Alzheimer's disease indicate that oxidative stress is an important factor in its pathogenesis. Studies have also suggested that cholesterol… (More)

Early induction of calpains in rotenone-mediated neuronal apoptosis

• Minghui Jessica Chen, Yann Wan Yap, +5 authors Nam Sang Cheung
• Neuroscience Letters
• 2006

Rotenone is an inhibitor of mitochondrial complex I that produces a model of Parkinson's disease (PD), where neurons undergo apoptosis by caspase-dependent and/or caspase-independent pathways.… (More)

U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases.

• Chor Hui Vivien Koh, Robert Z. Qi, +5 authors Nam Sang Cheung
• Cellular signalling
• 2006

Studies have suggested that cholesterol imbalance in the brain might be related to the development of neurological disorders such as Alzheimer's disease and Niemann-Pick disease type C. Previously,… (More)

Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons: Transcriptional responses and cellular pathways

• Zhao Feng Peng, Chor Hui Vivien Koh, +5 authors Nam Sang Cheung
• Neuropharmacology
• 2007

Studies have shown that the lipid peroxidation by-product, 4-hydroxynonenal (HNE), is involved in many pathological events in several neurodegenerative diseases. A number of signaling pathways… (More)

Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: microarray and proteomics analyses in cultured murine cortical neurons.

• Chor Hui Vivien Koh, Zhao Feng Peng, +4 authors Nam Sang Cheung
• Journal of cellular physiology
• 2007

Studies suggest that cholesterol imbalance in the brain might be related to the development of neurological disorders. U18666A is a well-known amphiphile which inhibits intracellular cholesterol… (More)

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