Learn More
When mitochondrial function is compromised and the mitochondrial membrane potential (Deltapsi(m)) falls below a threshold, the F(1)F(o)-ATP synthase can reverse, hydrolysing ATP to pump protons out of the mitochondrial matrix. Although this activity can deplete ATP and precipitate cell death, it is limited by the mitochondrial protein IF(1), an endogenous(More)
3D microfluidic cell culture systems offer a biologically relevant model to conduct micro-scale mammalian cell-based research and applications. Various natural and synthetic hydrogels have been successfully incorporated into microfluidic systems to support mammalian cells in 3D. However, embedment of cells in hydrogels introduces operational complexity,(More)
The functional integrity of mitochon-dria is strictly dependent on the molecular dynamics governing their shape, size, and structure. A sequence of fusion and fission events serve to tailor the mitochondrial reticulum and preserve its morphological and functional homeostasis. 1 The mito-chondrial ultrastructure, defined by the alignment and density of(More)
  • 1