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Mitochondrial structure has a central role both in energy conversion and in the regulation of cell death. We have previously shown that IF1 protects cells from necrotic cell death and supports cristae structure by promoting the oligomerisation of the F1Fo-ATPsynthase. As IF1 is upregulated in a large proportion of human cancers, we have here explored its(More)
The functional integrity of mitochon-dria is strictly dependent on the molecular dynamics governing their shape, size, and structure. A sequence of fusion and fission events serve to tailor the mitochondrial reticulum and preserve its morphological and functional homeostasis. 1 The mito-chondrial ultrastructure, defined by the alignment and density of(More)
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