Chooi Lee

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The emergence of obesity as a pandemic has led to increased efforts to determine the causes for this disorder and potential new treatments to prevent and/or treat those affected by it. The mechanisms underlying the ontogeny of obesity are complex. They involve an interaction between a genetic predisposition to this disorder and environmental conditions that(More)
Temozolomide (TMZ) is one of the most effective chemotherapeutic agents for glioblastoma multiforme, but the required high administration dose is accompanied by side effects. To overcome this problem and to further improve TMZ's efficacy, targeted delivery of TMZ by using polymeric nanoparticles has been explored. We synthesised the PLGA-PEG-FOL copolymer(More)
Obesity is a metabolic disorder and fundamental cause of other fatal diseases including atherosclerosis and cancer. One of the main factor that contributes to the development of obesity is high-fat (HF) consumption. Lipid ingestion will initiate from the gut feedback mechanisms to regulate glucose and lipid metabolisms. But these lipid-sensing pathways are(More)
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