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Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters
TLDR
Cryo-electron microscopy reconstructions of MCU channels from zebrafish and Cyphellophora europaea reveal a tetrameric architecture and shed light on the function of the channel, defining principles that underlie ion permeation and calcium selectivity in this unusual channel.
A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1
TLDR
The structural and biochemical experiments uncover the mechanism of the YTH domain in binding the DSR motif and help to elucidate the function of Mmi1.
Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
TLDR
The structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selectiveMitophagy.
A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing
TLDR
The authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise the role of EMC in facultative heterochromatin assembly and gene silencing and identifies an ERH interface required for interaction with an RNA binding protein.
Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function
Abstract Mitochondria are essential molecular machinery for the maintenance of cellular energy supply by the oxidative phosphorylation system (OXPHOS). Mitochondrial transcription factor B1 (TFB1M)
Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2
TLDR
A uniporter interaction domain on MICU1 binds to a channel receptor site comprising MCU and EMRE subunits to inhibit ion flow under resting Ca2+ conditions, indicating how Ca2-dependent changes enable dynamic response to cytosolic Ca2+.
Crystal structure of the two-subunit tRNA m1A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae
TLDR
The crystal structure of TRM6-TRM61 holoenzyme from Saccharomyces cerevisiae in the presence and absence of its methyl donor S-Adenosyl-L-methionine (SAM) is determined and provides a structural basis for better understanding the m1A58 modification of tRNA occurred in Saccharoma cerevisia.
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