Chongming Wu

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Hyperlipidemia is considered to be one of the greatest risk factors contributing to the prevalence and severity of cardiovascular diseases. In this work, we investigated the anti-hyperlipidemic effect and potential mechanism of action of the Pandanus tectorius fruit extract in hamsters fed a high fat-diet (HFD). The n-butanol fraction of the P. tectorius(More)
Decision-tree-based support vector machine which combines support vector machines and decision tree is an effective way for solving multi-class problems. A problem exists in this method is that the division of the feature space depends on the structure of a decision tree, and the structure of the tree relate closely to the performance of the classifier. To(More)
Based on analyzing the relationship between the Karush-Kuhn-Tucker (KKT) conditions of support vector machine and the distribution of the training samples, the possible changes of support vector set after new samples are added to training set was analyzed, and the generalized Karush-Kuhn-Tucker conditions was defined. Based on the classification equivalence(More)
In this work, we conducted functional analysis of Arabidopsis HRS1 gene in order to provide new insights into the mechanisms governing seed germination. Compared with wild type (WT) control, HRS1 knockout mutant (hrs1-1) exhibited significant germination delays on either normal medium or those supplemented with abscisic acid (ABA) or sodium chloride (NaCl),(More)
Chlorogenic acid (CGA) is one of the most abundant polyphenols in the human diet and is suggested to be a potential antiatherosclerotic agent due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study was to evaluate the effect of CGA on atherosclerosis development in ApoE(-/-) mice and its potential mechanism.(More)
Sophoricoside, an isoflavone glycoside isolated from Sophora japonica (Leguminosae), has been widely reported as an immunomodulator. In this study, the effects of sophoricoside on lipogenesis and glucose consumption in HepG2 cells and C2C12 myotubes were investigated. Treatment with sophoricoside at concentrations of 1-10 μM inhibited lipid accumulation in(More)
Cordycepin is a bioactive component of the fungus Cordyceps militaris. Previously, we showed that cordycepin can alleviate hyperlipidemia through enhancing the phosphorylation of AMP-activated protein kinase (AMPK), but the mechanism of this stimulation is unknown. Here, we investigated the potential mechanisms of cordycepin-induced AMPK activation in HepG2(More)
How to deal with the newly added training samples, and utilize the result of the previous training effectively to get better classification result fast are the main tasks of incremental learning. A fast SVM incremental learning algorithm based on the central convex hulls algorithm is proposed in this paper. To utilize the result of the previous training and(More)
To reduce the computational cost of the incremental learning, a fast SVM incremental learning algorithm based on the convex hulls algorithm is proposed in this paper. The given algorithm is based on utilizing the result of the previous training effectively and retaining the most important samples for the incremental learning to reduce the computational(More)