Chong-Sheng Yuan

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Treatment of 9-[6-(E)-(tributylstannyl)-5,6-dideoxy-2,3-O-isopropylidene-~-~-~ibo-hex-5-enofuranosylladenine [2b(E)1 or the 6-N-benzoyl derivative 2a(E) with iodine (or N-iodosuccinimide) or bromine (or N-bromosuccinimide) gave virtually quantitative and stereospecific conversions to the 6‘-(E)-(halohomovinyl)nucleoside analogues. Analogous treatment of the(More)
Vinylogously extended deoxyeritadenine derivatives were synthesized as acyclic/ carbocyclic analogues of the 6'-halo(homovinyl)adenosines, which are known to be potent inhibitors of S-adenosyl-L-homocysteine hydrolase. Swern oxidation of 9-[3-(t-butyldimethylsilyloxy)-4-hydroxybutyl]adenine (4) followed by Wittig olefination and desilylation gave access to(More)
S-Adenosylhomocysteine (AdoHcy) hydrolase regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolyzing the potent feedback inhibitor AdoHcy to homocysteine and adenosine. The crystallographic structure determination of a selenomethionyl-incorporated AdoHcy hydrolase inhibitor complex was accomplished using single wavelength anomalous(More)
Treatment of the 5′-carboxaldehyde derived by Moffatt oxidation of 6-N-benzoyl-2′,3′-Oisopropylideneadenosine (1) with the “(bromofluoromethylene)triphenylphosphorane” reagent and deprotection gave 9-(6-bromo-5,6-dideoxy-6-fluoro-â-D-ribo-hex-5-enofuranosyl)adenine (4). Parallel treatment with a “dibromomethylene Wittig reagent” and deprotection gave(More)
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