Chong-Hui Gu

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A novel multicompartment dissolution system was developed by modifying a conventional six-vessel United States Pharmacopoeia dissolution system to study the dissolution and possible precipitation of poorly soluble weak bases after oral administration. The modified system includes a "gastric" compartment, an "intestinal" compartment, an "absorption"(More)
To develop a statistical model for predicting effect of food on the extent of absorption (area under the curve of time–plasma concentration profile, AUC) of drugs based on physicochemical properties. Logistic regression was applied to establish the relationship between the effect of food (positive, negative or no effect) on AUC of 92 entries and(More)
The success rate of discovering new polymorphs by crystallization from solution may be increased if solvents with diverse properties are used during initial polymorph screening. In this study, eight solvent parameters, including hydrogen bond acceptor propensity, hydrogen bond donor propensity, polarity/dipolarity, dipole moment, dielectric constant,(More)
BMS-480188 is a weak base. The aqueous solubility of BMS-480188 is 0.036 mg/ml at pH 6.5 at 37 degrees C. The mesylate salt of BMS-480188 was prepared to improve its solubility. Capsules containing mesylate salt alone (Formulation A) or mesylate salt with excipients, including lactose, croscarmellose sodium, sodium lauryl sulfate, syloid and magnesium(More)
To correlate the polymer’s degree of precipitation inhibition of indomethacin in solution to the amorphous stabilization in solid state. Precipitation of indomethacin (IMC) in presence of polymers was continuously monitored by a UV spectrophotometer. Precipitates were characterized by PXRD, IR and SEM. Solid dispersions with different polymer to drug ratios(More)
Crystallization from solution is a technique widely used in various fields for separation and purification (1). During this process, structurally related impurities may be incorporated into the crystal lattice of the host crystals to form solid solutions (2,3). In addition, the solvent may also be incorporated into the host crystals as liquid inclusions(More)
During the discovery stage in lead identification/optimization, compounds are characterized for their solubilities in biorelevant media and these data are often used to model the in vivo behavior of the compounds and predict the fraction absorbed. These media are selected to closely approximate the composition of human intestinal fluid. Owing to the(More)
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