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Tumor progression largely depends on blood supply and neovessel formation, and angiogenesis is emerging as a promising target for cancer therapy. Vascular endothelial growth factor (VEGF), a major proangiogenic molecule, stimulates angiogenesis via promoting endothelial proliferation, survival and migration. VEGF has been found to be up-regulated in various(More)
INTRODUCTION Atrial fibrillation (AF) is associated with impaired coronary flow by means of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC). Mean platelet volume (MPV) is elevated in patients with AF. In the present study we aimed to investigate the relationship between MPV and TFC in patients with AF in the absence of obstructive coronary(More)
Angiogenesis is one of the earliest and essential phenotypes acquired by tumors during carcinogenesis and thus might be a potential target for chemoprevention. Key to developing antiangiogenic chemoprevention is to identify new molecular targets and effective angiogenesis inhibitors. HMG-CoA reductase inhibitors, or statins, were originally designed to(More)
To investigate the expression of calprotectin, the receptor of advanced glycation end products (RAGE) and tumor necrosis factor-α (TNF-α) in hypertensive disorders in pregnancy as well as the significance of their expression. The research assessed levels of plasma calprotectin and TNF-α using the enzyme-linked immunosorbent assay, and expression of(More)
PURPOSE We tested the combined effects of antiangiogenic endostatin and epidermal growth factor receptor (EGFR) antisense gene therapy on squamous cell carcinoma (SCC). EXPERIMENTAL DESIGN AND RESULTS The 1483 cell line of human head and neck SCC (HNSCC) and SCC-VII/SF murine SCC cells was used to establish tumors in nude mice and immunocompetent C3H(More)
Tumor growth and metastasis depend on blood supply and blood vessel formation. Angiogenesis, therefore, represents a promising target for cancer therapy. Endostatin is one of the most potent antiangiogenic factors and has been shown to effectively inhibit angiogenesis and tumor growth in a variety of in vivo models. In this study, we tested the effects of(More)
HMG-CoA reductase inhibitors (statins) have been shown to inhibit angiogenesis. The molecular mechanism mediating the anti-endothelial activities of statins remains unclear. The present study demonstrated that the antiangiogenic effect of atorvastatin (ATV) was associated with endothelial death. Molecular profiling data identified a 29-fold upregulation of(More)
The hypoxia-inducible factor 1α (HIF-1α) regulates transcriptional genes involved in cell proliferation, survival, and differentiation. Under normoxia, HIF-1α has a short half-life (t ½ ≈ 5 min) and low transcriptional activity. An HIF-1α mutant, produced by substitution of alanine (Ala) for proline (Pro) at position 564 and asparagine (Asp) at position(More)
Bone marrow derived stromal cells (MSCs) can prevent the apoptosis of ischemic cardiomyocytes (CMCs). This anti-apoptosis activity may be related to an activation of the HIF-1alpha signal pathway in MSCs. Therefore, we investigated protective effects of an adenovirus (Ad)-mediated active form of HIF-1alpha (HIF-1alpha-Ala564-Ala803) modified MSCs on CMCs(More)
OBJECTIVE To evaluate different expressions of high mobility group box 1 (HMGB1) and receptor for advanced glycation end products (RAGE) in placentas and their relationship with pre-eclampsia. METHODS Fifteen early-onset pre-eclamptic women (early-onset pre-eclampsia group), 22 late-onset pre-eclamptic women (late-onset pre-eclampsia group) and 12(More)