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BACKGROUND Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) offers a unique capability to probe tumour microvasculature. Different analysis of the acquired data will possibly lead to different conclusions. Therefore, the objective of this study was to investigate under which conditions the Tofts (TM), extended Tofts (ETM), compartmental tissue(More)
A novel airplane land based ramp ski-jump takeoff method via non-dominated sorting genetic algorithm II (NSGAII) was proposed. First, mathematic model and characteristic parameters of ramp runway were analyzed. Then, dynamic models of the whole takeoff process were given. After that, various constraints and restrictions were comprehensive considered. Later(More)
BACKGROUND Poor central nervous system penetration of cytotoxic drugs due to the blood brain barrier (BBB) is a major limiting factor in the treatment of brain tumors. Most recurrent glioblastomas (GBM) occur within the peritumoral region. In this study, we describe a hyperthemic method to induce temporary disruption of the peritumoral BBB that can(More)
PURPOSE To ascertain whether complex dynamic contrast enhanced (DCE) MRI tracer kinetic models are supported by data acquired in the clinic and to determine the consequences of limited contrast-to-noise. METHODS Generically representative in silico and clinical (cervical cancer) DCE-MRI data were examined. Bayesian model selection evaluated support for(More)
A 46MHz centre frequency, 2.046MHz bandwidth 6th order Chebyshev-I band pass integrated filter using a biquad Gm-C structure is designed and implemented. Negative resistance cells are used in the biquad structure to obtain high Q of the filter. The Tran conductor has a high linearity with source degeneration technique using MOS resistors. The whole filter(More)
A phosphane-catalyzed [4+1] annulation between nitroalkenes and Morita-Baylis-Hillman carbonates has been realized; this provides facile and diastereoselective access to polysubstituted isoxazoline N-oxides in moderate to excellent yields. In the annulation, an in situ formed allylic phosphorus ylide presumably serves as a pivotal active intermediate. This(More)
This paper presents a novel method that creates artistic video stylization for face area. Previous work has produced artistic stylized images based on the method of by-example synthesis that uses two sample images which are unfiltered image and filtered image and extends this method called image analogies to create video stylization. Since using the method(More)
This study aims to develop a constrained local arterial input function (cL-AIF) to improve quantitative analysis of dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) data by accounting for the contrast-agent bolus amplitude error in the voxel-specific AIF. Bayesian probability theory-based parameter estimation and model selection were used to(More)
A new phosphine-triggered tandem [3 + 4] annulation reaction between Morita-Baylis-Hillman carbonates and 1,4-diheteroatom dinucleophiles has been developed, which provides a facile synthetic method for saturated seven-membered 1,4-heterocycles such as 1,4-oxazepanes, 1,4-thiazepanes, and 1,4-diazepanes. Mechanistic investigation implies that this reaction(More)
Saturation-recovery measurements with Carr-Purcell-Meiboom-Gill sequences are commonly employed to measure the longitudinal relaxation time constant, T1, in grossly inhomogeneous fields. We show that in general the off-resonant effect generates unexpected extra signals in the T1 measurement. In the present study, we derive a modified T1 kernel that accounts(More)