Chloe K. Slichter
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MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly… Expand
Human Disc Nucleus Properties and Vertebral Endplate Permeability
Study Design. Experimental quantification of relationships between vertebral endplate morphology, permeability, disc cell density, glycosaminoglycan (GAG) content, and degeneration in samples… Expand
Distinct activation thresholds of human conventional and innate-like memory T cells.
Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation,… Expand
MAST: A flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA-seq data
Single-cell transcriptomic profiling enables the unprecedented interrogation of gene expression heterogeneity in rare cell populations that would otherwise be obscured in bulk RNA sequencing… Expand
Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation.
A key feature differentiating nonpathogenic SIV infection of sooty mangabeys (SMs) from pathogenic HIV/SIV infections is the rapid resolution of type I IFN (IFN-I) responses and IFN-stimulated gene… Expand
Measuring inhibition of HIV replication by ex vivo CD8⁺ T cells.
- Chloe K. Slichter, D. Friedrich, +5 authors N. Frahm
- Biology, Medicine
- Journal of immunological methods
- 1 February 2014
HIV replication is unrestrained in vivo in the vast majority of infected subjects, and the ability of some rare individuals to control this virus is poorly understood. Standard immunogenicity assays… Expand
The human tissue-resident CCR5+ T cell compartment maintains protective and functional properties during inflammation
- Amanda S Woodward Davis, Hayley N Roozen, +15 authors M. Prlic
- Biology, Medicine
- Science Translational Medicine
- 4 December 2019
Human CD69+CCR5+ T cells in mucosal tissues are poised to maintain barrier immunity in healthy and inflamed tissues. Tissue-resident T cells evade eviction CCR5 antagonism, explored in various… Expand
Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations
- Maxmillian Mpina, Nicholas J Maurice, +14 authors M. Prlic
- Medicine, Biology
- The Journal of Immunology
- 2 June 2017
Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following Plasmodium infection. IFN-γ production by… Expand
Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions.
Mucosal-associated invariant T cells (MAIT cells) recognize bacterial metabolites as antigen and are found in blood and tissues, where they are poised to contribute to barrier immunity. Recent data… Expand
Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells
- Erica S. Lovelace, Nicholas J Maurice, +6 authors S. J. Polyak
- Chemistry, Medicine
- PloS one
- 3 February 2017
Silymarin (SM), and its flavonolignan components, alter cellular metabolism and inhibit inflammatory status in human liver and T cell lines. In this study, we hypothesized that SM suppresses both… Expand