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MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either stronglyExpand
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Human Disc Nucleus Properties and Vertebral Endplate Permeability
Study Design. Experimental quantification of relationships between vertebral endplate morphology, permeability, disc cell density, glycosaminoglycan (GAG) content, and degeneration in samplesExpand
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Distinct activation thresholds of human conventional and innate-like memory T cells.
Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells) are found in blood, liver, and mucosal tissues and have similar effector potential following activation,Expand
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MAST: A flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA-seq data
Single-cell transcriptomic profiling enables the unprecedented interrogation of gene expression heterogeneity in rare cell populations that would otherwise be obscured in bulk RNA sequencingExpand
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Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation.
A key feature differentiating nonpathogenic SIV infection of sooty mangabeys (SMs) from pathogenic HIV/SIV infections is the rapid resolution of type I IFN (IFN-I) responses and IFN-stimulated geneExpand
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Measuring inhibition of HIV replication by ex vivo CD8⁺ T cells.
HIV replication is unrestrained in vivo in the vast majority of infected subjects, and the ability of some rare individuals to control this virus is poorly understood. Standard immunogenicity assaysExpand
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The human tissue-resident CCR5+ T cell compartment maintains protective and functional properties during inflammation
Human CD69+CCR5+ T cells in mucosal tissues are poised to maintain barrier immunity in healthy and inflamed tissues. Tissue-resident T cells evade eviction CCR5 antagonism, explored in variousExpand
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Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations
Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following Plasmodium infection. IFN-γ production byExpand
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Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions.
Mucosal-associated invariant T cells (MAIT cells) recognize bacterial metabolites as antigen and are found in blood and tissues, where they are poised to contribute to barrier immunity. Recent dataExpand
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Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells
Silymarin (SM), and its flavonolignan components, alter cellular metabolism and inhibit inflammatory status in human liver and T cell lines. In this study, we hypothesized that SM suppresses bothExpand
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