Chloe E Osborne

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Recent studies have demonstrated that neutrophils are not a homogenous population of cells. Here, we have identified a subset of human neutrophils with a distinct profile of cell-surface receptors [CD54(high), CXC chemokine receptor 1(low) (CXCR1(low))], which represent cells that have migrated through an endothelial monolayer and then re-emerged by reverse(More)
OBJECTIVE Synovial fibroblasts share a number of phenotype markers with fibroblasts derived from bone marrow. In this study we investigated the role of matched fibroblasts obtained from 3 different sources (bone marrow, synovium, and skin) to test the hypothesis that synovial fibroblasts share similarities with bone marrow-derived fibroblasts in terms of(More)
Experienced medical teachers were interviewed regarding creation and use of objectives for instruction. This paper summarizes reported advantages and disadvantages of objectives, describes reported changes in strategy with experience, and provides advice on the creation and use of objectives. Medical teachers agree that the process of writing objectives(More)
Recently, we identified aminothiazole derivatives of GE2270 A. These novel semisynthetic congeners, like GE2270 A, target the essential bacterial protein elongation factor Tu (EF-Tu). Medicinal chemistry optimization of lead molecules led to the identification of preclinical development candidates 1 and 2. These cycloalklycarboxylic acid derivatives show(More)
This paper reports the opinions of a representative sample of 1,329 physicians providing primary care regarding criteria developed by the Joint Committee on Quality Assurance for evaluation of ambulatory child health care. Areas of care were health supervision (in four age ranges), tonsillopharyngitis, bronchial asthma, and urinary infection. The criteria(More)
The joint Committee on Quality Assurance developed and validated by expert opinion a list of criteria for each of seven areas of ambulatory child health care: well-child supervision in four age ranges: bith to 1 year, 1 through 5 years, 6 through 12 years, and 13 through 18 years; and three diseases: bronchial asthma, tonsillopharyngitis, and urinary tract(More)
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting to detect proteins and glycoproteins is one of the most widely used and broadly useful techniques in cancer research, allowing the proteins in a complex sample--such as a blood sample, aspirate, or solid tumor homogenate--to be separated according to molecular weight(More)