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Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor.
Extracellular glycosylation is a critical determinant of malignant character. Here, we report that N-acetylgalactosaminyltransferase 2 (GALNT2), the enzyme that mediates the initial step of mucin… Expand
GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity.
- Mei-Chun Lin, Miao-Juei Huang, Chiung-Hui Liu, Tsung-Lin Yang, Min-Chuan Huang
- Biology, Medicine
- Oral oncology
- 1 May 2014
OBJECTIVES Oral squamous cell carcinoma (OSCC) is one of the leading cancers worldwide. Aberrant glycosylation affects many cellular properties in cancers, including OSCC. This study aimed to explore… Expand
C1GALT1 enhances proliferation of hepatocellular carcinoma cells via modulating MET glycosylation and dimerization.
- Yao-Ming Wu, Chiung-Hui Liu, +4 authors Min-Chuan Huang
- Biology, Medicine
- Cancer research
- 1 September 2013
Altered glycosylation is a hallmark of cancer. The core 1 β1,3-galactosyltransferase (C1GALT1) controls the formation of mucin-type O-glycans, far overlooked and underestimated in cancer. Here, we… Expand
C1GALT1 Promotes Invasive Phenotypes of Hepatocellular Carcinoma Cells by Modulating Integrin β1 Glycosylation and Activity
Cancer cell invasion and metastasis are the primary causes of treatment failure and death in hepatocellular carcinoma (HCC). We previously reported that core 1 β1,3-galactosyltransferase (C1GALT1) is… Expand
Millennial-scale changes in terrestrial sediment input and Holocene surface hydrography in the northern South China Sea (IMAGES MD972146)
Abstract This study presents a high-resolution, multi-proxy analysis of sediments from IMAGES core MD972146 in the northern South China Sea (SCS). Analyses include detailed measurements of planktonic… Expand
MUC1 Expression Is Increased During Human Placental Development and Suppresses Trophoblast-Like Cell Invasion In Vitro1
Abstract Mucin (MUC)1 is a multifunctional mucin expressed by a variety of reproductive tract epithelia. Trophoblast invasion is essential for normal placental development. However, MUC1 expression… Expand
Antioxidant prenylflavonoids from Artocarpus communis and Artocarpus elasticus
Abstract Two new prenylflavonoids, cyclogeracommunin (1) and artoflavone A (2), were isolated from the cortex of roots of Artocarpus communis. Their structures were determined by spectroscopic… Expand
Antioxidant triterpenoids from the stems of Momordica charantia
Abstract A new multiflorane triterpenoid and two new cucurbitane triterpenoids were isolated from the stems of Momordica charantia. The structures of the new compounds were elucidated by… Expand
β-1,4-Galactosyltransferase III suppresses β1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.
- Chia-Hua Chen, Shui-Hua Wang, +7 authors Min-Chuan Huang
- Chemistry, Medicine
- 1 June 2014
Metastasis often occurs in colorectal cancer (CRC) patients and is the main difficulty in cancer treatment. The upregulation of poly-N-acetyllactosamine-related glycosylation is found in CRC patients… Expand
Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.
- Chiung-Hui Liu, Chung-Yi Chen, A. Huang, Jih-Heng Li
- Biology, Medicine
- Journal of ethnopharmacology
- 1 September 2011
ETHNOPHARMACOLOGICAL RELEVANCE Cinnamomum subavenium has long been used as a traditional Chinese medicine to treat carcinomatous swelling, abdominal pain and other diseases. AIM OF THE STUDY The… Expand