Chitrani Medhi

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The mer-trichloro dimethylsulphoxide-S-(1,10-phenanthroline) ruthenium (III) ([Ru(phen)(DMSO)Cl3]) complex has been synthesized. The structure has been characterized from FT-IR, 1 H NMR and UV-Vis spectroscopic data. The geometry of this complex determined by single crystal X-ray diffraction study was found to be octahedral. The binding of this complex with(More)
Article history: Received on: 06/02/2017 Accepted on: 30/03/2017 Available online: 30/06/2017 Objectives: The present research work is designed to synthesize some new series of quinazoline-4-one/4-thione derivatives by modifying the structures retaining the fundamental structural features for the biological activity and screened for their anti-microbial,(More)
The anticancer drug, daunomycin undergoes various chemical processes such as reduction of chromophore, proton transfer inside chromophore and elimination of sugar moiety before binding with DNA sequences. Various chemical processes of daunomycin might be relevant for analyzing the sequence specific binding of this drug. The sequence specific DNA binding has(More)
The stacking of phenanthroline(phen) ligand within base pair sequences is one of the important factors for the stabilization of metalphen complex within DNA. The stacking ability of this ligand has been assessed to deduce the base pair selectivity as well as to identify the favored region of intercalation. Different level of theories have been used to(More)
The [Ru(DMSO)4Cl2] is a well known compound among the ruthenium complexes. Here, we report a unique binding of this compound with Calf Thymus DNA (CT-DNA) by spectroscopic and electrophoresis studies. The biological studies of this compound carried out in vivo and in vitro experiments on mice bearing with Dalton’s lymphoma were performed. The six(More)
The triple helix is formed by combining a double and a single strand DNAs in low pH and dissociates in high pH. Under such conditions, protonation of cytosine in the single strand is necessary for triplex formation where cytosine-guanine-cytosine (CGC+) base triplet stabilizes the triple helix. The mechanism of CGC+ triplet formation from guanine-cytosine(More)
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