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Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR.
Taxoids are anti-cancer drugs frequently used to treat solid tumors, but they are sometimes ineffective and tumors may become resistant to their action. Here, we examined the involvement ofExpand
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Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response.
Molecular hydrogen (H2) is a biologically active gas that is used medically to ameliorate various systemic pathological conditions. H2 also regulates gene expression involved in intracellularExpand
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BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells
Imatinib (IMT), a specific tyrosine kinase inhibitor (TKI), has drastically changed the treatment strategy for Ph+ ALL (Philadelphia chromosome-positive acute lymphoblastic leukemia). However, TKIExpand
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Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes
ABSTRACT Resveratrol (RSV) has recently attracted keen interest because of its pleiotropic effects. It exerts a wide range of health-promoting effects. In addition to health-promoting effects, RSVExpand
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Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.
T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase inhibitors including imatinib and is only responsiveExpand
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MOLECULAR HYDROGEN IS A NOVEL ANTIOXIDANT TO REDUCE OXIDATIVE STRESS AND ATTENUATE DISEASE PROGRESSION THROUGH MODIFICATION OF CELL SIGNALING AND GENE EXPRESSIONS
Molecular hydrogen (H2) is an agent with potential applications in oxidative stress-related and/or inflammatory disorders. The treatment of hydrogen-containing air (HCA) and hydrogen-rich water (HRW)Expand