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Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR.

• Yuka Aoyama, Sayaka Sobue, +8 authors Takashi Murate
• Biochemical and biophysical research…
• 2017

Taxoids are anti-cancer drugs frequently used to treat solid tumors, but they are sometimes ineffective and tumors may become resistant to their action. Here, we examined the involvement of… (More)

BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells

• Chisato Inoue, Sayaka Sobue, +9 authors Takashi Murate
• Biochemistry and biophysics reports
• 2018

Imatinib (IMT), a specific tyrosine kinase inhibitor (TKI), has drastically changed the treatment strategy for Ph+ ALL (Philadelphia chromosome-positive acute lymphoblastic leukemia). However, TKI… (More)

Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response.

• Sayaka Sobue, Chisato Inoue, Fumiko Hori, Shanlou Qiao, Takashi Murate, Masatoshi Ichihara
• Biochemical and biophysical research…
• 2017

Molecular hydrogen (H2) is a biologically active gas that is used medically to ameliorate various systemic pathological conditions. H2 also regulates gene expression involved in intracellular… (More)

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