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- Publications
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Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR.
- Yuka Aoyama, S. Sobue, +8 authors T. Murate
- Biology, Medicine
- Biochemical and biophysical research…
- 29 April 2017
Taxoids are anti-cancer drugs frequently used to treat solid tumors, but they are sometimes ineffective and tumors may become resistant to their action. Here, we examined the involvement of… Expand
Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response.
- S. Sobue, Chisato Inoue, Fumiko Hori, S. Qiao, T. Murate, M. Ichihara
- Biology, Medicine
- Biochemical and biophysical research…
- 4 November 2017
Molecular hydrogen (H2) is a biologically active gas that is used medically to ameliorate various systemic pathological conditions. H2 also regulates gene expression involved in intracellular… Expand
BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells
- Chisato Inoue, S. Sobue, +9 authors T. Murate
- Chemistry, Medicine
- Biochemistry and biophysics reports
- 13 July 2018
Imatinib (IMT), a specific tyrosine kinase inhibitor (TKI), has drastically changed the treatment strategy for Ph+ ALL (Philadelphia chromosome-positive acute lymphoblastic leukemia). However, TKI… Expand
Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes
- Chisato Inoue, S. Sobue, +9 authors T. Murate
- Chemistry, Medicine
- Nagoya journal of medical science
- 8 November 2019
ABSTRACT Resveratrol (RSV) has recently attracted keen interest because of its pleiotropic effects. It exerts a wide range of health-promoting effects. In addition to health-promoting effects, RSV… Expand
Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.
- Chisato Inoue, S. Sobue, +7 authors Takahsi Murate
- Chemistry, Medicine
- Biochemical and biophysical research…
- 14 March 2020
T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase inhibitors including imatinib and is only responsive… Expand
Molecular hydrogen attenuates chronic inflammation and thus leads to the delayed manifestation of the initial lesions of UV-induced skin cancer in mice.
- Ryoma Shinchi, Fumiko Hori, S. Sobue, Chisato Inoue, M. Ichihara
- Chemistry
- 8 November 2019
MOLECULAR HYDROGEN IS A NOVEL ANTIOXIDANT TO REDUCE OXIDATIVE STRESS AND ATTENUATE DISEASE PROGRESSION THROUGH MODIFICATION OF CELL SIGNALING AND GENE EXPRESSIONS
- S. Sobue, Chisato Inoue, Fumiko Hori, M. Ito, K. Ohno, M. Ichihara
- Biology
- 25 January 2016
Molecular hydrogen (H2) is an agent with potential applications in oxidative stress-related and/or inflammatory disorders. The treatment of hydrogen-containing air (HCA) and hydrogen-rich water (HRW)… Expand