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A world of possibilities: Gold-catalyzed reactions of 2-ethynylbenzyl ethers with organic oxides and α-diazoesters gave 1,3-dihydroisobenzofuran and naphthalene derivatives, respectively (see scheme; EWG = electron-withdrawing group). Mechanisms for the formation of the formal cycloadducts were elucidated by isotope labeling.
Selective synthesis of 1- and 3-substituted 2-methoxyindenes from the carboalkoxylations of 2-ethynylbenzyl ethers is described; the former is obtained efficiently with P(t-Bu)2(o-biphenyl)AuCl/NaBARF in DCM/MS 4 Å whereas the latter is produced preferably with P(t-Bu)2(o-biphenyl)AuCl/AgNTf2 in pre-dried DCM. Both 1- and 3-substituted 2-indenyl ethers are… (More)
We reported a new synthesis of 2-aryl-2H-indazoles via a silver-catalyzed [3+2]-cycloaddition of benzynes with diazocarbonyl reagents. We postulate that this transformation involves the generation of (1H-indazol-1-yl)silver to activate a subsequent arylation with the second benzyne.
Two distinct Pt-catalyzed carboalkoxylations of alkynes are reported. The cycloisomerization of 5-alkoxypent-1-yn-3-ol derivatives 5 produces 2,6-dioxabicyclo[3.1.0]hexanes 6; the mechanism is postulated to involve a hydroxyl-triggered [3.3]-sigmatropic allyl rearrangement. As the same catalysis is extensible to their tertiary alcohol analogues 7, distinct… (More)