Chinmay Y. Majmudar

Publications17
h-index11
Citations460
Highly Influential Citations25
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Mocr: a novel fusion tag for enhancing solubility that is compatible with structural biology applications.
A persistent problem in heterologous protein production is insolubility of the target protein when expressed to high level in the host cell. A widely employed strategy for overcoming this problem is… Expand
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Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors.
Small molecules that reconstitute the binding mode(s) of a protein and in doing so elicit a programmed functional response offer considerable advantages in the control of complex biological… Expand
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Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo.
Currently there are few methods suitable for the discovery and characterization of transient, moderate affinity protein-protein interactions in their native environment, despite their prominent role… Expand
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Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.
Capturing a coactivator, naturally: the natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the… Expand
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Ordering a dynamic protein via a small-molecule stabilizer.
Like many coactivators, the GACKIX domain of the master coactivator CBP/p300 recognizes transcriptional activators of diverse sequence composition via dynamic binding surfaces. The conformational… Expand
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Targeting the transcriptional machinery with unique artificial transcriptional activators.
The link between a growing number of human diseases and misregulation of gene expression has spurred intense interest in artificial transcriptional activators that could be used to restore controlled… Expand
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A high-resolution interaction map of three transcriptional activation domains with a key coactivator from photo-cross-linking and multiplexed mass spectrometry.
Transcriptional activators play a central role in gene regulation, stimulating the assembly of the transcriptional machinery at a promoter in a signal responsive manner.[1] Because of the significant… Expand
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Impact of nonnatural amino acid mutagenesis on the in vivo function and binding modes of a transcriptional activator.
Protein-protein interactions play an essential role in cellular function, and methods to discover and characterize them in their native context are of paramount importance for gaining a deeper… Expand
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Functional specificity of artificial transcriptional activators.
Misregulated transcription is linked to many human diseases, and thus artificial transcriptional activators are highly desirable as mechanistic tools and as replacements for their malfunctioning… Expand
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Converting inactive peptides into potent transcriptional activators.
Significant efforts have been devoted to the development of artificial transcriptional activators for use as mechanistic tools, as therapeutic agents, and for biomanufacturing applications. One of… Expand
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