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T cell hybridomas isolated from nonresponder H-2 b mice immunized with pork insulin were stimulated by insulin in the presence of major histocompatibility complex (MHC)-unmatched antigen presenting cells. The restriction element used by these CD4 Ϫ T cells was mapped to an oligomorphic MHC class Ib protein encoded in the T region and identified as Qa-1 b(More)
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