• Publications
  • Influence
Sertoli-Germ Cell Anchoring Junction Dynamics in the Testis Are Regulated by an Interplay of Lipid and Protein Kinases*
TLDR
Results illustrate that Sertoli-germ cell anchoring junction dynamics in the testis are regulated, at least in part, via the β1-integrin/PI3K/PKB/ERK signaling pathway.
Regulation of blood-testis barrier dynamics: an in vivo study
TLDR
The results demonstrate for the first time that the TGF-β3/p38 MAP kinase signaling pathway is being used to regulate both TJ and AJ dynamics in the testis, mediated by the effects of T GF- β3 on TJ- and AJ-integral membrane proteins and adaptors, but not protease inhibitors.
Phosphorylation of the src Epithelial Substrate Trask Is Tightly Regulated in Normal Epithelia but Widespread in Many Human Epithelial Cancers
TLDR
The widespread phosphorylation of Trask in many human epithlelial cancers identifies a new potential effector of SRC kinases in human epithelial tumorigenesis.
Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling
TLDR
The effects of Trask phosphorylation on cell adhesion, integrin activation, clustering, and focal adhesion signaling are studied to reveal a novel pathway through which Src kinases can oppose integrin-mediated cellAdhesion.
A male contraceptive targeting germ cell adhesion
TLDR
Using a novel approach in which Ad judin is specifically targeted to the testis by conjugating Adjudin to a recombinant follicle-stimulating hormone (FSH) mutant, which serves as its 'carrier', infertility was induced in adult rats and represents a substantial increase in AdjudIn's selectivity and efficacy as a male contraceptive.
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes.
TLDR
Data suggest that the apical ES is a cell-cell adherens junction type with the characteristics of cell-matrix focal contacts, and in addition to its role in conferring cell adhesion formation, the p-FAK/c-Src protein complex apparently also regulates apicalES disruption via the ERK signaling pathway.
Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: a review of recent data.
TLDR
An integrated model of how these three MAPKs regulate adhesion function in the seminiferous epithelium is presented, which will serve as the framework for future investigation in the field.
Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-beta-catenin protein complex which are possibly mediated by c-Src and
TLDR
The results illustrate that the cadherin/catenin is a crucial cell adhesion complex that regulates AJ dynamics in the testis, and its functionality is likely modulated by the MTMR2/c-Src protein complex.
...
1
2
3
4
...