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Sertoli-Germ Cell Anchoring Junction Dynamics in the Testis Are Regulated by an Interplay of Lipid and Protein Kinases*
- M. Siu, Ching-hang Wong, Will M. Lee, C. Cheng
- Biology, MedicineJournal of Biological Chemistry
- 1 July 2005
Results illustrate that Sertoli-germ cell anchoring junction dynamics in the testis are regulated, at least in part, via the β1-integrin/PI3K/PKB/ERK signaling pathway.
Regulation of blood-testis barrier dynamics: an in vivo study
The results demonstrate for the first time that the TGF-β3/p38 MAP kinase signaling pathway is being used to regulate both TJ and AJ dynamics in the testis, mediated by the effects of T GF- β3 on TJ- and AJ-integral membrane proteins and adaptors, but not protease inhibitors.
The blood-testis barrier: its biology, regulation, and physiological role in spermatogenesis.
Phosphorylation of the src Epithelial Substrate Trask Is Tightly Regulated in Normal Epithelia but Widespread in Many Human Epithelial Cancers
- Ching-hang Wong, F. Baehner, +7 authors M. Moasser
- Medicine, BiologyClinical Cancer Research
- 1 April 2009
The widespread phosphorylation of Trask in many human epithlelial cancers identifies a new potential effector of SRC kinases in human epithelial tumorigenesis.
Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling
- D. Spassov, Ching-hang Wong, +4 authors M. Moasser
- Medicine, BiologyMolecular and Cellular Biology
- 28 December 2010
The effects of Trask phosphorylation on cell adhesion, integrin activation, clustering, and focal adhesion signaling are studied to reveal a novel pathway through which Src kinases can oppose integrin-mediated cellAdhesion.
AF-2364 [1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide] is a potential male contraceptive: a review of recent data.
A male contraceptive targeting germ cell adhesion
Using a novel approach in which Ad judin is specifically targeted to the testis by conjugating Adjudin to a recombinant follicle-stimulating hormone (FSH) mutant, which serves as its 'carrier', infertility was induced in adult rats and represents a substantial increase in AdjudIn's selectivity and efficacy as a male contraceptive.
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes.
- Ching-hang Wong, W. Xia, Nikki P Y Lee, D. Mruk, Will M. Lee, C. Cheng
- Biology, MedicineEndocrinology
- 1 March 2005
Data suggest that the apical ES is a cell-cell adherens junction type with the characteristics of cell-matrix focal contacts, and in addition to its role in conferring cell adhesion formation, the p-FAK/c-Src protein complex apparently also regulates apicalES disruption via the ERK signaling pathway.
Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: a review of recent data.
An integrated model of how these three MAPKs regulate adhesion function in the seminiferous epithelium is presented, which will serve as the framework for future investigation in the field.
Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-beta-catenin protein complex which are possibly mediated by c-Src and…
The results illustrate that the cadherin/catenin is a crucial cell adhesion complex that regulates AJ dynamics in the testis, and its functionality is likely modulated by the MTMR2/c-Src protein complex.