Ching-Yi Hsieh

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With an information explosion on the molecular mechanism of oncogenesis, the completion of the human genome sequence project, and the advances in genomic and proteomic methods, many therapeutic targets for various cancers have been identified. It is timely that a number of new drug development techniques have been developed in this last decade. Candidate(More)
A complex sum method of quantifying the magnetic susceptibility of a long, narrow cylinder embedded in a uniform medium has been developed. The radius of the cylinder can be as small as one pixel. The susceptibility inside the object is extracted from the magnetic resonance complex images, using two concentric circles around the axis of the cylinder. The(More)
A new procedure for accurately measuring effective magnetic moments of long cylinders is presented. Partial volume, dephasing and phase aliasing effects are naturally included and overcome in our approach. Images from a typical gradient echo sequence at one single echo time are usually sufficient to quantify the effective magnetic moment of a(More)
AG 879 has been widely used as a Tyr kinase inhibitor specific for ErbB2 and FLK-1, a VEGF receptor. The IC(50) for both ErbB2 and FLK-1 is around 1 microM. AG 879, in combination of PP1 (an inhibitor specific for Src kinase family), suppresses almost completely the growth of RAS-induced sarcomas in nude mice. In this paper we demonstrate that AG 879 even(More)
Recently a method called CISSCO (Complex Image Summation around a Spherical or a Cylindrical Object) was introduced for accurately quantifying the susceptibility and the radius of any narrow cylindrical object at any orientation using a typical two-echo gradient echo sequence. This work further optimizes the method for quantifying oxygen saturation in small(More)
A new method is developed to measure the magnetic susceptibilities and radii of small cylinder-like objects at arbitrary orientations accurately. This method for most biological substances only requires a standard gradient echo sequence with one or two echo times, depending on the orientation of an object relative to the main magnetic field. For objects(More)
PURPOSE The ACR MRI accreditation program requires measurement of the magnetic field homogeneity (MFH) in the annual QA. Full implementation of vendor methods can be very time consuming and incorporates techniques not available to clinical physicists. Conversely, many of the less involved techniques proposed tend to be less inaccurate and/or precise. Here,(More)
Misregistration due to cardiac motion causes artifacts in two-exposure dual-energy subtraction images, in both the soft-tissue-only image and the bone-only image. Two previous investigations have attempted to avoid misregistration artifacts by using cardiac gating of the first and second exposures. The severity of misregistration was affected by the heart(More)
Genistein, found in soy products, is a phytochemical with several biological activities. In the current study, our research focused on the estrogenic and proliferation-inducing activity of genistein. We have dem onstrated that genistein enhanced the proliferation of estrogen-dependent human breast cancer (MCF-7) cells in vitro at concentrations as low as 10(More)
Genistein, found in soy products, is a phytochemical with several biological activities. In the current study, our research focused on the estrogenic and proliferation-inducing activity of genistein. We have dem onstrated that genistein enhanced the proliferation of estrogen-dependent human breast cancer (MCF-7) cells in vitro at concentrations as low as 10(More)