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Asymmetric zinc-Reformatsky reaction of Evans chiral imide with acetophenones and its application to the stereoselective synthesis of triazole antifungal agents
Formal synthesis of the ACE inhibitor benazepril x HCl via an asymmetric aza-Michael reaction.
A formal enantioselective synthesis of benazepril is reported, an anti- hypertensive drug, and the synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester to 4-(2-nitrophenyl)-4-oxo- but-2-enoic acid methyl ester as the key step.
Structurally well-characterized zinc complexes bearing imine-benzotriazole phenoxide ligands: Synthesis, photoluminescent properties and catalysis for carbon dioxide/epoxide coupling
Dialkylative cyclization reactions of 3-sulfolenes with 1,3-diiodopropane and 1,2-bis(bromomethyl)benzene
We have shown that dialkylative cyclization reactions of 3-sulfolenes with dihalo substrates provide bridged bicyclic [3.2.1] and [4.2.1] systems. The competitive bicyclization reactions giving…
Synthesis of optically active α-aminobenzolactam via an oxidative–cyclization reaction
Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive reaction
An efficient synthesis of the C27-C45 fragment of lagunamide A, a cyclodepsipeptide with potent cytotoxic and antimalarial properties
Determination of trace indium in urine after preconcentration with a chelating-resin-packed minicolumn.
- Hui-ming Liu, Ching-Yao Chang, Chia-Chan Wu, Jian-Ming Wei, Wei-Yu Chen, C. Yeh
- ChemistryJournal of separation science
- 1 April 2012
The method developed was successfully applied to analysis of spiked urine samples with good recoveries of 93-103% (n = 6) and reproducibility (relative standard deviation < 4.9%).
BF3-promoted synthesis of diarylhexahydrobenzo[f]isoquinoline.
- Meng‐Yang Chang, Chung-Han Lin, Yeh-long Chen, Ching-Yao Chang, Ru-Ting Hsu
- ChemistryOrganic letters
- 1 March 2010
The overall transformation from 4-arylpiperidin-3-one to benzo[f]isoquinoline proceeds via ring contraction, chain elongation, and intramolecular electrophilic cyclization in moderate yields and presents a novel rearrangement reaction catalyzed by boron trifluoride etherate.
A Short and Efficient Synthesis of a Novel Diarylheptanoid Isolated from Pleuranthodium Racemigerum
- Ching-Yao Chang
- 1 June 2011
The first total synthesis of the linear diarylheptanoid 1-(4″-methoxyphenyl)-7-(4′-hydroxyphenyl)-(E)-hept-2-ene, which has a uniquely nonconjugated olefin, was achieved. The synthetic route employed…