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Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction.
It is well known that compression speed can have significant effects on the compaction properties of pharmaceutical powders. This is a challenge during scale up and technology transfer when tabletingExpand
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Pre-absorption physicochemical compatibility assessment of 8-drug metabolic cocktail.
A comprehensive 8-drug metabolic cocktail was designed to simultaneously target 6 Cytochrome P450 enzymes and 2 membrane transporters. This study aimed to assess the pre-absorption risk of this newExpand
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Abstract 1643: BMS-983970, an oral pan-Notch inhibitor for the treatment of cancer
Deregulation of the Notch pathway has been shown to be oncogenic in numerous tissue types including T-cell acute lymphoblastic leukemia (T-ALL), breast cancer, non-small cell lung cancer, andExpand
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Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.
We describe our efforts to identify structurally diverse leads in the triazole-containing N1-carboline series of bromodomain and extra-terminal inhibitors. Replacement of the N5 "cap" phenyl moietyExpand
Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes
TLDR
The discovery environment is characterized by short timelines, scarce supplies of drug, a wide range of chemical space, suboptimal compounds, and the need to execute in a parallel fashion. Expand