Chinaka Onyebuchi Nwaehujor

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Plan: The anti-diabetic and anti-hyperlipidemic effects of D-3-O-methylchiroinositol were investigated in male Wistar rats. Methodology: Diabetes was induced by a single intra-peritoneal injection of 150 mg/kg of alloxan monohydrate. Five groups of rats comprising six animals in each group were used including a positive control group (glibenclamide, 2(More)
BACKGROUND Wound healing is a natural process that enables tissue repair after an injury. To shorten its duration and minimize associated complications, wounds are treated with medications. Currently there is a growing interest in the use of alternative wound dressing agents such as plant extracts. One plant used traditionally in wound treatment is Pupalia(More)
The natives of Orba in Udenu, Enugu State, Nigeria use the roots of Stephania dinklagei to treat folkloric “sugar disease.” The methanol root extract of S. dinklagei was investigated for antidiabetic activity in alloxan-induced diabetic Wistar rats and also evaluated for in vitro and in vivo antioxidant potentials. Extraction was by cold maceration in 80 %(More)
Objective. Mallotus oppositifolius (Geiseler) Müll. Arg. (Euphorbiaceae) is folklorically used to "treat" diabetic conditions in some parts of Nigeria therefore the study, to investigate the extract of the leaves for activities on hyperglycaemia, lipid peroxidation, and increased cholesterol levels in vivo in alloxan diabetic rats as well as its potential(More)
OBJECTIVE To explore the hepatoprotective and anti-oxidant activities of the methanolic leaf extract of Bridelia micrantha (B. micrantha) on paracetamol induced liver damage in Wistar rats. METHODS Parameters were measured including alanine aminotransaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin and total protein.(More)
BACKGROUND Ethnopharmacological practitioners in Nigeria have used aqueous and ethanol extracts of Bridelia micrantha leaves to manage conditions associated with inflammation, and these include diabetes, chest pain, edema, arthritis and joint pains. This study aimed to evaluate the effects of methanol leaf extract of B. micrantha on chronic inflammation and(More)
Sarcocephalus latifolius, the African peach, is one greatly cherished, eaten and widely distributed shrubs mainly in the closed woodland savannah, and has been used to treat diverse diseases in some African and Asia populations. In Southern Nigeria, ‘herbal doctors’ include its leaves in decoctions given to patients of varying degrees of suspected liver(More)
The aim of this study was to assess the effects of Allium cepa aqueous extract on red blood cell membrane stability and oxidative stress in streptozotocin-induced diabetic Wistar rats. Various alterations of red blood cell (RBC) membrane appear both in diabetes mellitus and during the physiological aging processes. Diabetes mellitus decreases the life span(More)
In humans, malaria in pregnancy can cause serious maternal and foetal morbidity and in extreme untreated cases, foetal mortality occurs. The therapeutic approach to curbing this malaise is the administration of an effective and/or combinations of anti-malaria medicaments. Acute or chronic administration of some of these drugs, however, gives rise to some(More)
D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for analgesic, anti-inflammatory and anti-pyretic activities. The compound was screened for analgesic activity by the acetic acid-induced writhing and tail immersion tests. The anti-inflammatory activities were evaluated by the carrageenan-induced paw edema and(More)