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Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging.
All eukaryotic cells divide a finite number of times, although the mechanistic basis of this replicative aging remains unclear. Replicative aging is accompanied by a reduction in histone proteinExpand
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Chromatin reassembly signals the end of DNA repair
The packaging of the eukaryotic genome into chromatin provides a formidable obstacle to the machinery that mediates genomic processes such as transcription, repair and replication. The cell solvesExpand
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Establishment of a mini-gene expression database for bladder tumor.
BACKGROUND AND PURPOSE Transitional cell carcinoma has been diagnosed mostly in urinary bladder in southern Taiwan and has an exceptionally high mortality rate. To identify the genes associated withExpand
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Knowledge-based simulation of bunkering services in the port of Kaohsiung
Bunkering services are complex and require experienced engineers to make bunker barge allocation decisions. We have developed a knowledge-based simulation model to evaluate overall systemExpand
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Selective sensitization of cancer cells to DNA damage by a HAT inhibitor
Comment on: Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer- specific chemo-and radiosensitization. Keya Bandyopadhyay, Jean-Louis Banères, Aimée Martin, Casimir Blonski,Expand
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SYSTEM SIMULATION FOR THE EVALUATION OF THE OIL BARGE OPERATION IN KAOHSIUNG HARBOR, TAIWAN. IN: MARITIME ENGINEERING AND PORTS III
The oil barge operation in Kaohsiung harbor is a typical system of resource allocation problems in a complex and dynamic environment. Such a system is far more difficult to deal with than a staticExpand