Chin-Yuan Chang

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Streptothricin-F (STT-F), one of the early-discovered antibiotics, consists of three components, a β-lysine homopolymer, an aminosugar D-gulosamine, and an unusual bicyclic streptolidine. The biosynthesis of streptolidine is a long-lasting but unresolved puzzle. Herein, a combination of genetic/biochemical/structural approaches was used to unravel this(More)
With the rapid development of network hardware technologies and network bandwidth, the high link speeds and huge amount of threats poses challenges to network intrusion detection systems, which must handle the higher network traffic and perform more complicated packet processing. In general, pattern matching is a highly computationally intensive process(More)
Breast masses with a radiologic stellate pattern often transform into malignancies, but their tendency to be of low histologic grade yields a better survival rate compared with tumors with other patterns on mammography screening. This study was designed to investigate the correlation of histologic grade with stellate features extracted from the coronal(More)
Utilization of N-acetylhexosamine in bifidobacteria requires the specific lacto-N-biose/galacto-N-biose pathway, a pathway differing from the Leloir pathway while establishing symbiosis between humans and bifidobacteria. The gene lnpB in the pathway encodes a novel hexosamine kinase NahK, which catalyzes the formation of N-acetylhexosamine 1-phosphate(More)
Teicoplanin A2-2 (Tei)/A40926 is the last-line antibiotic to treat multidrug-resistant Gram-positive bacterial infections, e.g., methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE). This class of antibiotics is powered by the N-acyltransferase (NAT) Orf11*/Dbv8 through N-acylation on glucosamine at the central(More)
Due to the fast growth of multimedia content, the digital preservation emerges as an important technology that prolongs the life of digital objects. For audio-visual contents, we face the obsolescence problem in both supporting hardware/software and data representation formats. Migration strategy is a solution for achieving high-quality archival and easy(More)
This paper presents a neural solution for clustering without pre-specifying the number of clusters. The presented clustering approach incorporates a harmonic neural network (HNN) and a codeword-agglomerating neural network (ANN). The HNN harmonizes criteria of mean squared error and information entropy to exploit the substructure in the input data and find(More)
Polystyrene-divinylbenzene copolymer functionalized with copper-iminodiacetate complex was prepared in situ for the capillary electrochromatographic separation of amino acids and oligopeptides. The steps included silanization of the fused-silica capillary column, functionalization, polymerization, hydrolysis and complexation. For having a homogeneous(More)
Telematics systems are becoming important digital products in near future. However, the most of current telematics systems are isolated from the networks. All of the services are embedded on one single system that has caused lack of diverse information services, and want a more powerful embedded system to support. In this paper, an architecture of cloud(More)