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RATIONALE Pulmonary arterial hypertension (PAH) is a lethal, female-predominant, vascular disease. Pathologic changes in PA smooth muscle cells (PASMC) include excessive proliferation, apoptosis-resistance, and mitochondrial fragmentation. Activation of dynamin-related protein increases mitotic fission and promotes this proliferation-apoptosis imbalance.(More)
PURPOSE The objective of this study was to assess the prognostic value of metabolic tumor burden on 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG) positron emission tomography (PET)/CT measured with metabolic tumor volume (MTV) and total lesion glycolysis (TLG), independent of Union Internationale Contra la Cancrum (UICC)/American Joint Committee on Cancer(More)
BACKGROUND The possibility that μ opioid agonists can influence cancer recurrence is a subject of recent interest. Epidemiologic studies suggested that there were differences in cancer recurrence in breast and prostate cancer contingent on anesthetic regimens. In this study, we identify a possible mechanism for these epidemiologic findings on the basis of μ(More)
Segmentation of thoracic X-Ray Computed Tomography images is a mandatory pre-processing step in many automated or semi-automated analysis tasks such us region identification, densitometric analysis, or even for 3D visualization purposes when a stack of slices has to be prepared for surface or volume rendering. In this work, we present a fully automated and(More)
PURPOSE To prospectively investigate the effect of using Gemstone Spectral Imaging (GSI) and adaptive statistical iterative reconstruction (ASIR) for reducing radiation and iodine contrast dose in abdominal CT patients with high BMI values. MATERIALS AND METHODS 26 patients (weight > 65kg and BMI ≥ 22) underwent abdominal CT using GSI mode with 300mgI/kg(More)
The discrete Gabor (1946) transform algorithm is introduced that provides an efficient method of calculating the complete set of discrete Gabor coefficients of a finite-duration discrete signal from finite summations and to reconstruct the original signal exactly from the computed expansion coefficients. The similarity of the formulas between the discrete(More)
For pt. I see ibid., p. 1386-93 (1995). An approach applying artificial neural net techniques to 3D nonrigid motion analysis is proposed. The 3D nonrigid motion of the left ventricle of a human heart is examined using biplanar cineangiography data, consisting of 3D coordinates of 30 coronary artery bifurcation points of the left ventricle and the(More)
Reports on a new method in which spatially correlated magnetic resonance (MR) or X-ray computed tomography (CT) images are employed as a source of prior information in the Bayesian reconstruction of positron emission tomography (PET) images. This new method incorporates the correlated structural images as anatomic templates which can be used for extracting(More)