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Gene regulation is dynamic across cellular conditions and disease subtypes. From the aspect of regulation under modulation, regulation strength between a pair of genes can be modulated by (dependent on) expression abundance of another gene (modulator gene). Previous studies have demonstrated the involvement of genes modulated by single modulator genes in(More)
Next generation sequencing (NGS) has been widely used in biological and medical researches. NGS facilitates identifying mutations and differentially expressed genes that are causative to diseases. However, its high-throughput feature poses major challenges in performing the analysis, especially the alignment step. The alignment step is critical in the NGS(More)
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