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AIM Acute bronchiolitis is the commonest cause for hospitalisation in infancy. Supportive care remains the cornerstone of current management and no other therapy has been shown to influence the course of the disease. It has been suggested that adding nebulised hypertonic saline to usual care may shorten the duration of hospitalisation. To determine whether(More)
BACKGROUND Non-invasive ventilation is part of the standard of care for treatment of respiratory failure in patients with amyotrophic lateral sclerosis (ALS). The NeuRx RA/4 Diaphragm Pacing System has received Humanitarian Device Exemption approval from the US Food and Drug Administration for treatment of respiratory failure in patients with ALS. We aimed(More)
BACKGROUND Acute bronchiolitis is the commonest cause of hospitalisation in infancy. Currently management consists of supportive care and oxygen. A Cochrane review concluded that, "nebulised 3 % saline may significantly reduce the length of hospital stay". We conducted a systematic review of controlled trials of nebulised hypertonic saline (HS) for infants(More)
BACKGROUND Motor neurone disease (MND) is a devastating illness which leads to muscle weakness and death, usually within 2-3 years of symptom onset. Respiratory insufficiency is a common cause of morbidity, particularly in later stages of MND and respiratory complications are the leading cause of mortality in MND patients. Non Invasive Ventilation (NIV) is(More)
BACKGROUND Standard treatment of Duchenne muscular dystrophy (DMD) includes regular physiotherapy. There are no data to show whether adding aquatic therapy (AT) to land-based exercises helps maintain motor function. We assessed the feasibility of recruiting and collecting data from boys with DMD in a parallel-group pilot randomised trial (primary(More)
DIABETIC retinopathy is a common cause of blindness. The introduction of photo-coagulation treatment has stimulated interest in this condition and several well designed and properly controlled studies have shown that either xenon arc or argon laser photocoagulation therapy can arrest or delay the progression of diabetic retinopathy.1-7 This treatment is now(More)
We treated a selected group of patients with superior-half bullous retinal detachments by preoperative bed rest and immobilisation of the affected eye using a temporary inferior rectus suture taped to the brow. Sufficient flattening of the retina was achieved in each case to permit successful simple extrascleral detachment surgery.
Twenty-eight patients with bullous superior half retinal detachments were treated by pre-operative binocular occlusion, retrobulbar Bupivicaine hydrochloride and ocular immobilization using a temporary inferior rectus suture taped to the patient's forehead. Sufficient pre-operative flattening of the retina was achieved in each case to permit successful(More)
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in death, usually from respiratory failure, within 2-3 years of symptom onset. Non-invasive ventilation (NIV) is a treatment that when given to patients in respiratory failure leads to improved survival and quality of life. Diaphragm pacing (DP), using the NeuRx/4(®)(More)
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