Learn More
Evidence of LRRK2 haplotypes associated with Parkinson’s disease (PD) risk was recently found in the Chinese population from Singapore, and a common LRRK2 missense variant, Gly2385Arg, was independently detected as a putative risk factor for PD in the Chinese population from Taiwan. To test the association between the Gly2385Arg variant in a large(More)
Excessive synchronization of the basal ganglia neuronal activity in the 13- to 35-Hz frequency band, so-called beta activity, has been associated with the motor deficits of Parkinson's disease (PD). Studies have demonstrated that beta activity may be suppressed by treatment with dopaminergic medication and high-frequency stimulation of the subthalamic(More)
Chronic high frequency stimulation of the subthalamic nucleus (STN) of the basal ganglia is a highly effective treatment for Parkinson's Disease (PD). Such deep brain stimulation is thought to suppress spontaneous, including pathological, activity in the basal ganglia [1–5]. Equally, however, it must also remove any residual physiological functioning in(More)
Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate whether externally imposed synchronization(More)
Excessive synchronization of basal ganglia neural activity at low frequencies is considered a hallmark of Parkinson's disease (PD). However, few studies have unambiguously linked this activity to movement impairment through direct stimulation of basal ganglia targets at low frequency. Furthermore, these studies have varied in their methodology and findings,(More)
Excessive synchronization of basal ganglia neuronal activity at ~20 Hz is characteristic of patients with untreated Parkinson's disease (PD). Correlative evidence suggests that this activity may contribute to bradykinesia. Attempts to demonstrate causality through stimulation imposed synchronization at 20 Hz in the region of the subthalamic nucleus (STN)(More)
We propose an adaptive load balancing algorithm for heterogeneous distributed systems. The algorithm intrinsically allows a batch of tasks to be relocated. The key of the algorithm is to transfer a suitable amount of processing demand from senders to receivers. This amount is determined dynamically during sender-receiver negotiations. Factors considered(More)
Processor thrashing in load distribution refers to the situation when a number of nodes try to negotiate with the same target node simultaneously. The performance of dynamic load balancing algorithms can be degraded because processor thrashing can lead to receiver node overdrafting, thus causing congestions at a receiver node and reduction of workload(More)
A dynamic load distribution (LD) algorithm improves the performance of a distributed system by using current system load information to relocate application tasks among processing nodes so that workload imbalance in the system can be smoothed out. In this paper, we propose a Guarantee and Reservation Protocol (GR Protocol) which can be used by dynamic LD(More)