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  • Severine Crettol, Jean-Jacques Déglon, +5 authors Chin B. Eap
  • Medicine
  • Clinical pharmacology and therapeutics
  • 2006 (First Publication: 1 December 2006)
  • BACKGROUND AND OBJECTIVE The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. We aimed to thoroughly examine the genetic factorsContinue Reading
  • Caroline Flora Samer, Youssef Daali, +7 authors Jules Alexandre Desmeules
  • Medicine
  • British journal of pharmacology
  • 2010 (First Publication: 1 June 2010)
  • BACKGROUND AND PURPOSE The major drug-metabolizing enzymes for the oxidation of oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the activity of these enzymes because of geneticContinue Reading
  • Caroline Flora Samer, Youssef Daali, +7 authors Jules Alexandre Desmeules
  • Medicine, Chemistry
  • British journal of pharmacology
  • 2010 (First Publication: 1 June 2010)
  • BACKGROUND AND PURPOSE There is high interindividual variability in the activity of drug-metabolizing enzymes catalysing the oxidation of oxycodone [cytochrome P450 (CYP) 2D6 and 3A], due to geneticContinue Reading