Chikkam V V S N Murty

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The effect of the administration of tryptophan on the transport of nuclear poly (A)-containing mRNA to the cytoplasm in rat liver was investigated. Administration of tryptophan to fasted rats pretreated with cordycepin and actinomycin D led to decreased levels of nuclear poly (A)-mRNA and a concomitant increase in the levels of polyribosomal poly (A)-mRNA(More)
The effect of the administration of L-tryptophan or tryptophan-related compounds on rat liver RNA and protein metabolism was investigated. The five biochemical parameters studied were polyribosomal aggregation, protein synthesis in vitro, synthesis of cytoplasmic poly(A)-mRNA, release of labeled nuclear RNA in vitro (nuclear and cell sap effects) and(More)
The possible role that informosomal mRNA may play in the stimulation of hepatic protein synthesis induced by the acute administration of tryptophan was investigated. L-tryptophan (30 mg/100 g body weight) tube-fed to rats induced an increase (20%) in the amount of polyribosome-associated poly(A+)mRNA in the liver within 1 hour. On the other hand, the amount(More)
Tryptophan has been demonstrated earlier to induce in the livers of rats and mice a rapid stimulation of polyribosomal aggregation and protein synthesis which has been attributed in part to stimulation of translocation of nuclear mRNA into the cytoplasm. This study was concerned with how tryptophan acts to affect the nuclei, particularly the nuclear(More)
The administration of tryptophan to fasted rats 1 hour before killing resulted in marked increases in the amounts of hepatic polyriboadenylic acid (poly(A)) and poly(a)-containing-mRNA in the cytoplasm and a shift in hepatic polyribosomes toward heavier aggregates. When animals were treated with cordycepin, or actinomycin D, to both, there was(More)
It has been demonstrated earlier that the administration of tryptophan to fasted animals increased the levels of mRNA in the cytoplasm of the liver by stimulating the translocation of nuclear poly(A)-mRNA into the cytoplasm. Also, tryptophan increased the activity of hepatic nuclear envelope (NE) nucleoside triphosphatase, an enzyme considered to be(More)
Tryptophan induces a rapid stimulation of polyribosomal aggregation and protein synthesis in the livers of rats or mice. This stimulatory effect of tryptophan correlates with increased levels of mRNA in the cytoplasm of the liver and is related to enhanced translocation of nuclear mRNA into the cytoplasm. In the present study the possible role of(More)