Chikahiko Naito

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BACKGROUND Erythrocytes contain a large amount of glutathione (GSH), which protects cells from oxidative injury. The purpose of this study was to examine whether hemoglobin (Hb) is modified with glutathione by oxidation of the thiol groups in diabetes mellitus and hyperlipidemia, and to determine the oxygen affinity of glutathionyl Hb. METHODS Hb samples(More)
We first detected glutathionyl hemoglobin (Hb) beta-chain in hemodialysis patients and healthy subjects using electrospray ionization liquid chromatography-mass spectrometry. The ratio of glutathionyl Hb beta-chain to total beta-chain was markedly increased in the hemodialysis patients as compared with healthy subjects. Glutathionyl Hb will be used as a new(More)
By using electrospray ionization liquid chromatography-mass spectrometry, we demonstrated that glutathionyl hemoglobin (Hb)beta-chain levels are markedly increased in the erythrocytes of diabetic patients as compared with healthy subjects. The administration of vitamin E to the diabetic patients for 8 weeks significantly decreased the levels of glutathionyl(More)
The concentration and affinity of luteinizing hormone (LH) receptors in bovine luteal tissues during the oestrous cycle and pregnancy were investigated by Scatchard analysis of the binding of 125I-labeled human chorionic gonadotropin. Corpora lutea (CL) were classified into five stages of the oestrous cycle and three stages of pregnancy. The concentration(More)
The tenthredlnld sawflles Macrophya apicalis and M. infumata, which range throughout Japan and adjacent areas, are very similar in external morphology and share the same host plant, Sambucus sieboldiana. We Investigated their genetic distances within the genus and their lntraspecific variation, and estimated their time of divergence to clarify the history(More)
It was shown that accumulated fat in the liver originated mainly from dietary fat in chronic alcoholic fatty liver, while it came mainly from depot fat in acute alcoholic fatty liver. To investigate the main origin of accumulated fat in the liver in subacute fatty liver, we perfrormed the following experiments. We also examined the relationship, if any,(More)
To obtain an accurate criterion as to the diagnosis of serum hepatitis, liver function tests were performed at regular intervals af ter the surgical operation or blood transfusion, and also investigated on the correlation between those and histological findings of liver biopsy specimen. Results obtained were as follows; 1) None of elevation of S-GOT and GPT(More)
tively. 0.4g ot sulfonated polyetyrene cation exchanger (mesh beat 40, I .R. 120) which was washed previously was mixed with 2.0m/ of heparinized test plasma in a stoppered test tube. After 5 minutes of stirring, the mixture was centrifuged and the sedimented resine was washed with about 4ml of destilled water 4 times. And then 2 m / o f sodium phenoxide(More)