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Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestryExpand
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A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
  • Y. Wu, He Gao, +47 authors E. Tai
  • Biology, Medicine
  • Human molecular genetics
  • 15 February 2014
Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels haveExpand
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Association analyses of East Asian individuals and trans‐ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels
&NA; Large‐scale meta‐analyses of genome‐wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total cholesterol (TC), high‐densityExpand
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Is Hyperuricemia Another Facet of the Metabolic Syndrome?
Background: Hyperuricemia is commonly associated with obesity, glucose intolerance, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. The resemblance of the metabolic syndromeExpand
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Effects of Subacute Hypothyroidism on Metabolism and Growth-Related Molecules
Thyroid hormones are crucial hormones that primarily regulate the metabolism of entire body cells. In this study, Sprague-Dawley rats were grouped into sham thyroidectomy (Sham Tx), thyroidectomyExpand
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Uric acid and the development of hypertension.
Uric acid is a major product of purine metabolism in humans. Epidemiologic and experimental evidence suggests that serum uric acid is an independent risk factor for developing hypertension. SeveralExpand
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Acarbose improves glycemic control in insulin-treated Asian type 2 diabetic patients: results from a multinational, placebo-controlled study.
The purpose of the study was to determine the efficacy and tolerability of acarbose in Asian type 2 diabetic patients insufficiently controlled by insulin. Asian type 2 diabetic patients on stableExpand
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Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci.
Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, theExpand
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Clinical and biochemical indicators of homeostasis model assessment‐estimated insulin resistance in postmenopausal women
Background: Homeostasis model assessment of insulin resistance (HOMA‐IR) is a surrogate estimate of directly measured insulin resistance that been robustly proven to be associated with diabetes andExpand
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Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific
BackgroundMetabolic abnormalities have a cumulative effect on development of diabetes, but only central obesity has been defined as the essential criterion of metabolic syndrome (MetS) by theExpand
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