Chihiro Homma

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A fundamental issue in cortical processing of sensory information is whether top-down control circuits from higher brain areas to primary sensory areas not only modulate but actively engage in perception. Here, we report the identification of a neural circuit for top-down control in the mouse somatosensory system. The circuit consisted of a long-range(More)
BACKGROUND To reduce adverse reactions due to platelet (PLT) transfusion, medical solutions on the market, such as saline and ACD-A, are used to replace the plasma of PLT concentrates in Japan; however, they are not strongly preservative. Here, an attempt was made to develop a novel additive solution (M-sol) having the ability to preserve PLTs stably, with(More)
Understanding how emotion is generated, how conflicting emotions are regulated, and how emotional states relate to sophisticated behaviors is a crucial challenge in brain research. Model animals showing selective emotion-related phenotypes are highly useful for examining these issues. Here, we describe a novel mouse model that withdraws in(More)
BACKGROUND Leukodepletion reduces but does not eliminate adverse reactions to platelet concentrate (PC). As an alternative strategy, plasma reduction or washing of platelets should be considered. However, the efficacy of this strategy is still unclear. STUDY DESIGN AND METHODS A total of 12 patients who experienced adverse reactions at a 29 to 100 percent(More)
BACKGROUND AND OBJECTIVES We previously developed a novel additive solution (M-sol) with a high ability to preserve the in vitro qualities of platelets (PLTs) in washed PLTs Here, we compared the ability of M-sol with that of commercially available additive solutions (ASs) to preserve the in vitro qualities (pH, mean PLT volume, %disc, P-selectin,(More)
The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface receptors. In diabetes and Alzheimer's disease, pathological progression is accelerated by activation of RAGE. However, how RAGE influences gross behavioral activity patterns in basal condition has not been(More)
The marble burying test is a simple behavioral psychopharmacology task in which rodents, especially rats and mice, are exposed to glass marbles laying on thick bedding materials. This test has been widely used to assess the effects of a variety of psychoactive drugs. Although the marble burying test clearly reflects drug efficacy, many aspects of the(More)
Dear Sir, Universal leucocyte reduction of blood components has been widely implemented to reduce the risk of transfusion reactions (Beckman et al., 2004). The residual numbers of leucocytes are required to be <1× 106 cells per blood product and <5× 106 cells per blood product in the European and American guidelines, respectively (U.S. Food and Drug(More)