Chihiro Homma

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A fundamental issue in cortical processing of sensory information is whether top-down control circuits from higher brain areas to primary sensory areas not only modulate but actively engage in perception. Here, we report the identification of a neural circuit for top-down control in the mouse somatosensory system. The circuit consisted of a long-range(More)
Understanding how emotion is generated, how conflicting emotions are regulated, and how emotional states relate to sophisticated behaviors is a crucial challenge in brain research. Model animals showing selective emotion-related phenotypes are highly useful for examining these issues. Here, we describe a novel mouse model that withdraws in(More)
The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface receptors. In diabetes and Alzheimer's disease, pathological progression is accelerated by activation of RAGE. However, how RAGE influences gross behavioral activity patterns in basal condition has not been(More)
The marble burying test is a simple behavioral psychopharmacology task in which rodents, especially rats and mice, are exposed to glass marbles laying on thick bedding materials. This test has been widely used to assess the effects of a variety of psychoactive drugs. Although the marble burying test clearly reflects drug efficacy, many aspects of the(More)
Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) was originally identified in patients with seizures. It is densely distributed in the hip-pocampus and amygdala in particular. Because the expression of Arc/Arg3.1 is regulated by nerve inputs , it is thought to be an immediate early gene. As shown both in vitro and in vivo, Arc/Arg3.1 is(More)
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