Chihiro Akiba

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A 62-year-old male presented with a rare case of possible neuro-Sweet Disease (NSD) mimicking brain tumor in the medulla oblongata, manifesting as numbness in the bilateral upper and lower extremities, gait disturbance, dysarthria, and swallowing disturbance which gradually deteriorated over 3 months. Magnetic resonance imaging showed a mass lesion in the(More)
BACKGROUND Patients presenting with the classical idiopathic normal pressure hydrocephalus (iNPH) triad often show additional parkinsonian spectrum signs. Accurate differential diagnosis strongly influences the long-term outcome of cerebrospinal fluid (CSF) shunting. OBJECTIVE The aim of this study was to find potential CSF microRNA (miRNA) biomarkers for(More)
The roles of antidiuretic hormone (ADH) and aldosterone in the elicited diuretic responses of trained and untrained men to seated, supine, and head-out water immersed conditions were studied. Volunteers were comprised of groups of six untrained individuals, six trained swimmers, and six trained runners. Each subject underwent three protocols, six hours in a(More)
OBJECTIVE In Japan, idiopathic normal pressure hydrocephalus (iNPH) currently is treated mainly with lumboperitoneal (LP) shunts. Our aim was to evaluate whether LP shunting via the use of Medtronic Strata NSC programmable valves was as effective as ventriculoperitoneal shunting in the treatment of patients with iNPH from the perspectives of safety and(More)
We previously reported increase in leucine-rich α2-glycoprotein (LRG) concentration in cerebrospinal fluid is associated with cognitive decline in humans. To investigate relationship between LRG expression in the brain and memory impairment, we analyzed transgenic mice overexpressing LRG in the brain (LRG-Tg) focusing on hippocampus. Immunostaining and(More)
Chondroid chordoma (CC) is a rare but commonest subtype of chordoma with little reported clinical information. The present study summarizes and updates present knowledge of CC. Literature search for demographic data and clinical appearance of cranial CCs except for those entirely confined to the sinonasal region. A total of 48 English language papers(More)
Water immersion (WI) of anesthetized dogs to the midcervical level in the vertical sitting position under thermoneutral conditions (38 degrees C) leads to generalized increases in regional blood flows (radiolabeled microspheres) to most tissues. The increased flows can be accounted for by increased local VO2 in some tissues (heart, respiratory muscle), or(More)
A 33-year-old male became aware of a painless soft mass in the left occipital region. His medical and family history were unremarkable for neurofibromatosis type 1 (NF1) or other genetic disorders. Physical examination showed no signs of NF1. Neurological and ophthalmological examinations found no abnormality. Cranial computed tomography showed an isodense(More)
Methods Study participants were selected according to hospital bed capacity, using a random sampling method. In a primary survey, the number of iNPH patients in each hospital department during the year 2012 was estimated for stratification of institutions and next, in a secondary survey, selected patients provided detailed information, determining the(More)